SCH did not affect the activity of the mutant Pgp F983A suggesting that SCH acted differently than the thioxanthene type of Pgp allosteric inhibitors. Our results suggest that SCH acts by affecting the normal formation and functioning of the Pgp-substrate complexes. [ 125I]IAAP:[ 125I]-...
Schisandrol A from Schisandra chinensis Reverses P-Glycoprotein-Mediated Multidrug Resistance by Affecting Pgp-Substrate Complexes. Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexes [J]. Planta Med, 2007, 73... WF Fong - ...
GRIND base 3D QSAR eval Pgp substrate pharmacophore (Caco-2 efflux)Cianchetta, G
Provided are anti-cancer compounds which act as a non-PGP substrate, same being compounds of formula I-1, or a pharmaceutically acceptable salt, a prodrug or a solvate thereof, and the medical use of these compounds in the treatment of cancers, tumors, conditions caused by cancers or tumors...
Provided are anti-cancer compounds which act as a non-PGP substrate, same being compounds of formula I-1, or a pharmaceutically acceptable salt, a prodrug or a solvate thereof, and the medical use of these compounds in the treatment of cancers, tumors, conditions caused by cancers or tumors...
The synthesis of the DNA fragment, d(CpTpGpGpApTpCpCpApG), using a long-chain alkylamine-controlled pore glass bead polymer support, crystalline (9-phenyl-9-xanthenyl) nucleosides, and the bifunctional phosphorylating reagent, bis(1-benzotriazolyl)-2-chlorophenyl phosphate is described. For high...
SAHA is a substrate of the brain efflux transporters Pgp and Bcrp1.Jesse E. HansonHank LaEmile PliseYungHsiang ChenXiao DingTaleen HananiaEmily V. SabathVadim AlexandrovDani BrunnerEmer Leahy