同时,TOF患者心肌线粒体DNA相对拷贝数在统计学上显著增高(图1)。TFAM是一种核编码因子,可转运到线粒体,与线粒体DNA的D环结合,激活其复制和转录。TFAM是由PGC-1α通过与NRFs共活化而调控的。据报道,PGC-1α表达的增加也增加了线粒...
NRF1是分子警察,负责侦测自由基信号,对细胞内氧化还原状态非常敏感。NRF1继续激活TFAM【线粒体转录因子】的启动子,产生TFAM蛋白质因子,转运进入线粒体内,结合到线粒体DNA【mtDNA】,于是激活了RNA聚合酶,开始行使线粒体基因组的转录工作。 下图是线粒体DNA【mtDNA】,上面居住着37个基因: 电子传递链复合体Ⅰ:NADH脱...
TFAM (D5C8) Rabbit mAb #8076 100 µl NRF1 (D9K6P) Rabbit mAb #46743 100 µl DRP1 (D6C7) Rabbit mAb #8570 100 µl Product Information Product Usage Information ApplicationDilution Western Blotting 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 ...
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling Mengbo Yang, Xinda Chen, Ming Zhang, Xiaolin Zhang, Dongdong Xiao, Huiming Xu & Mujun Lu Biological Research vol...
PGC-1α特别与NRF-1和NRF-2的相互作用以转激活参与呼吸链的基因,线粒体进入机制和线粒体DNA的转录因子,如Tfam,TFB1M和TFB2M。此外,研究结果显示,通过与NRF-1结合和NRF-1的诱导,PGC-1α能刺激这线粒体大量增殖。最近,雌激素相关受体ERRα,也被认为氧化代谢的重要调节因子。有证据表明,ERRα的活性不仅由PGC...
In VHL wild-type cells, PGC-1a suppression leads to decreased expression of the mitochondrial tran- scription factor Tfam and impaired mitochondrial respiration. Conversely, PGC-1a expression in VHL- deficient cells restores mitochondrial function and induces oxidative stress. ccRCC cells expressing PGC...
We found that BDNF significantly enhances PGC-1a, NRF1 and TFAM expression and mitochondrial biogenesis in cultured hippocampal neurons. A functional CRE site in the PGC-1a co-activator gene, which is activated by BDNF-induced activation of ERKs and CREB, mediates PGC-1a expression and ...
结果DOX以浓度-依赖性的方式降低AC16细胞存活率,增加线粒体内ROS水平,降低线粒体膜电位,减少线粒体DNA拷贝数;DOX降低线粒体新生相关蛋白PGC-1a,NRF1,TFAM,VDAC和COXⅣ蛋白表达水平,抑制线粒体新生;DOX降低p62蛋白表达水平,增加Beclin1蛋白表示水平,同时增加LC3Ⅱ蛋白表达水平,诱导AC16细胞发生自噬;此外,DOX促进...
电针"足三里"穴对脾气虚大鼠心肌PGC-1α/NRFs/TFAM信号通路表达的影响 采用荧光定量PCR法检测大鼠心肌组织PGC-1α、NRF1、NRF2、TFAM的mRNA表达水平。采用Western Blot检测大鼠心肌组织PGC-1α及NRF1的蛋白表达水平。结果:与正常组相比,... 刘路,张立德,曲怡,... - 《中华中医药学刊》...
Figure 2 | Effects of PGC-1a plasmid and TFAM siRNA co-transfection on mitochondrial biogenesis in a human MFH cell line, Nara-H. (a) Protein expression of PGC-1a and TFAM were evaluated by immunoblot analysis in Nara-H cells that were co-transfected with PGC-1a plasmid (or control ...