PGC-1a负责线粒体和细胞核之间的互动,因为线粒体DNA【mtDNA】和细胞核DNA【nDNA】上有两套基因组,它们必须通力合作才能保证我们活着。 下图的含义,就是逐级激活,PGC-1a激活了NRF1的启动子,产生NRF1蛋白质因子。NRF1是分子警察,负责侦测自由基信号,对细胞内氧化还原状态非常敏感。NRF1继续激活TFAM【线粒体转录因子】...
The latter studies also provided evidence that the transcription factor NRF1/2 mediates the effects of PGC-1a on the expression of nuclear genes encoding mitochondrial proteins including the mitochondrial transcription factor (TFAM), which is essential for the initiation of mtDNA transcription and ...
结果DOX以浓度-依赖性的方式降低AC16细胞存活率,增加线粒体内ROS水平,降低线粒体膜电位,减少线粒体DNA拷贝数;DOX降低线粒体新生相关蛋白PGC-1a,NRF1,TFAM,VDAC和COXⅣ蛋白表达水平,抑制线粒体新生;DOX降低p62蛋白表达水平,增加Beclin1蛋白表示水平,同时增加LC3Ⅱ蛋白表达水平,诱导AC16细胞发生自噬;此外,DOX促进...