Neurodegenerative disorders are characterized by the progressive loss of structure and function of neurons, often including the death of the neuron. Previously, we reported that, by removing the cell death stimulus, dying/injured neurons could survive and recover from the process of regulated cell dea...
研究目的:线粒体是真核生物进行氧化代谢的场所,是细胞的"能量工厂".PGC-1a是能量代谢路径中众多转录因子的共同激活因子,在能量代谢平衡和线粒体生物合成中起到至关重要的作用.长期耐力运动能提高机体的有氧耐力,众多研究均表明这与骨骼肌线粒体的合成提高有关,可能导致其数量的增加及功能的改善,但具体分子机制尚不...
Aims/hypothesis We investigated whether skeletal muscle peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1A; also known as PPARGC1A) and its target mitofusin-2 (MFN2), as well as carnitine palmitoyltransferase-1 (CPT1; also known as carnitine palmitoyltransferase 1A [liver] ...
Therefore, identification of pharmacological agents that activate PGC-1a in human muscle or that target the muscle-derived factors, which mediate the retrograde signaling in this context, is of high clinical importance. Thus, similar to our current understanding of the potential deployment of ''...
Impaired PGC-1a function in muscle in Huntingtons disease 喜欢 0 阅读量: 18 作者: Chaturvedi,R.,K.,Adhihetty,P.,Shukla,S.,Hennessy,T.,Calingasan,N.,Yang,L.,Starkov,A.,Kiaei,M.,Cannella,Sassone,J. 展开 年份: 2009 收藏 引用 批量引用 报错 分享 ...