结论:成功构建小鼠 PGC-1a 基因启动子报告质粒,证实 PGC-1a 基因上游区域(-2533-+78)具有较强的启动子活性;启动子区域中的 CRE 和 IRE 反应原件为主要转录调控位点。关键词:细胞生物学;PGC-1a;启动子;转录调控中图分类号:Q291 Cloning and Analyzing the Promoter of Mouse PGC-1a Gene RAN Li1, TU Jing...
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but ...
Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells[J]. Gene, 2002, 286(1): 81-89. 4. Fan W, Evans R. PPARs and ERRs: molecular mediators of mitochondrial metabolism[J]. Curr Opin Cell Biol, 2015, 33: 49-54....
Gene Symbol PGC1a Gene ID (NCBI) 10891 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q9UBK2 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting ...
NGF gene delivery in AD patients showed an increase in brain energy metabol... Li-Wen,Chen,Lin-Yea,... - 《Neuropharmacology》 被引量: 19发表: 2012年 Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental ...
Print datasheet MSDS ¥2800/100 μL Cat No.CL488-66369 浓度:1000 μg/ml 库存:现货 Size 点击咨询在线客服 PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM (RNA recognition motif) domain and local...
Gene ID (NCBI)10891 RRIDAB_2828002 ConjugateUnconjugated FormLiquid Purification MethodProtein A purification Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage ConditionsStore at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.20ul si...
Besides controlling postsynaptic NMJ gene expression, PGC-1a is a key regulatory nexus of endurance exercise adaptation in the skeletal muscle. Accordingly, PGC-1a levels are strongly regulated by physical activity21. Upon activation, PGC-1a promotes many, if not all of the adaptations of muscle ...
gene clonered musclewhite muscle目的:获得齐口裂腹鱼过氧化物酶体增殖物激活受体Y辅助活化因子1a(PGC-1a)cDNA序列,探讨其在齐口裂腹鱼肌肉组织中的表达规律。方法:根据斑马鱼基因PGC-1a序列设计引物,提取齐口裂腹鱼肌肉组织总RNA,经RT-PCR扩增PGC-1a仪基因序列;利用半定量RT-PCR分析齐口裂腹鱼PGC-1a基因在...
(-2533-+78)andconstructedthe30pGL3-PGC-1a-Lucreportervectoranditsmutants.ThetranscriptionactivitywasanalyzedbyLuciferaseassay.PCRwasusedtoobtainDNAfragmentsthatcontainthepromoterofPGC-1agenebyusinggenomeDNApreparedfrommouseliverasthetemplates.ReporterplasmidspGL3-PGC-1a-Lucwhichcontainwild-typeormutant-type...