NRF1miR-378aVSMC functionsBackground and aimsAtherosclerosis (AS) is the leading cause of cardiovascular diseases. PGC-1α is a key regulator of cellular energy homeostasis, but its role in AS remains debatable. Methods and resultsIn our study, PGC-1α was shown to be significantly decreased ...
The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α–NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats Objective. To test the hypothesis that salidroside (SAL) can protect heart from exhaustive exercise-induced injury by enhancing mi...
BACKGROUND: Mitochondria may participate in the complex process that vascular smooth muscle cells transform tram contractile state to synthetic state.OBJECTIVE: To observe the effect of PGC-1/NRF-1/mtTFA pathway associated with mitochondrial function on the proliferation of vascular smooth muscle cells....
然而,虾青素以浓度依赖的方式恢复了 Δ残基(图3f)。此外,虾青素显著提高肝细胞中核呼吸因子1(nRF1)和线粒体转录因子蛋白 A (TFAM)的表达,而 FFA 负荷减少了这两种物质的表达(图3g)。通过电子显微镜观察线粒体形态的变化(图3h)。除了脂滴外,我们还观察到 FFA 加载后线粒体中的一些脂质内含物,以及线粒体肿胀、...
PGC-1α regulates the expression of nuclear and mitochondrial genes that encode components of the electron transport system and oxidative phosphorylation (OXPHOS) machinery via the coactivation of nuclear respiratory factors 1 (NRF1) and estrogen-related receptors α, β, and γ (ERR-α, -β and...
PGC1α最早发现其可以调控线粒体生成相关基因的转录,如核呼吸因子 1/2(nucleartranscriptionfactors1/2,NRF1/2),线粒体转 录因子(mitochondrialtranscriptionfactorA,TFAM)以及细胞核编码线粒体基因,如细胞色素氧化酶 4亚基(cytochromeCoxidasesubunit4,COXIV),从而促进线粒体的生成,满足不同细胞、组织在不同生理病理...
即本发明的ARβ2-PKA-PGC-1α激活剂、SIRT1激活剂、AMPK激活剂和Nrf-2激活剂通过直接和/或间接启动PGC-1α基因表达,和/或通过结构调节激活PGC-1α活性。总活性增强的PGC-1α通过诱导核呼吸因子1(nuclearrespiratoryfactors1,NRF1)、核呼吸因子2(nuclearrespiratoryfactors2,NRF2,也称为GABP)基因表达。进而通过NRF...
心肌线粒体生物发生及PGC 1 的中心作用平 政综述 曹雪滨审校 摘要 强制性激活心脏线粒体生物发生会导致心肌肥厚、心力衰竭等病理现象。线粒体生物发生有赖于核基因编码蛋白的合成输入、线粒体DNA复制和线粒体融合与分裂的协调发生。过氧化物酶体增殖物激活受体辅激活因子(PGC 1 )在线粒体生物发生中发挥了中心作用...
PGC-1α及其相关转录因子在糖尿病肾病及肾脏衰老中作用的研究 《pgc-1α及其相关转录因子在糖尿病肾病及肾脏衰老中作用的研究》xx年xx月xx日
Given the important links between mitochondria and synapses and that PGC-1α is involved in the regulation of mitochondrial function, western blotting was used to examine the expression of the mitochondrial proteins UCP2 (dimer), NRF1 and mtTFA, which are classical indicators of mitochondrial function...