PGC-1a负责线粒体和细胞核之间的互动,因为线粒体DNA【mtDNA】和细胞核DNA【nDNA】上有两套基因组,它们必须通力合作才能保证我们活着。 下图的含义,就是逐级激活,PGC-1a激活了NRF1的启动子,产生NRF1蛋白质因子。NRF1是分子警察,负责侦测自由基信号,对细胞内氧化还原状态非常敏感。NRF1继续激活TFAM【线粒体转录因子】...
NRF1/nuclear respiratory factor 1 Polyclonal antibody 12482-1-AP ER Polyclonal antibody 21244-1-AP PPAR Gamma Polyclonal antibody 16643-1-AP PPARGC1B Polyclonal antibody 22378-1-AP PPARA Polyclonal antibody 15540-1-AP PPARD Polyclonal antibody 10156-2-AP NRF1/nuclear respiratory factor 1 Polycl...
NRF1 (D9K6P) Rabbit mAb #46743 100 µl DRP1 (D6C7) Rabbit mAb #8570 100 µl Product Information Product Usage Information ApplicationDilution Western Blotting 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0....
(a,b) Effects of BDNF on PGC-1a, NRF1 and TFAM mRNA and protein levels in cultured hippocampal neurons. Cultured hippocampal neurons (7 days in culture) were treated with 40 ng ml À 1 BDNF for the indicated time periods. mRNA (by quantitative PCR) and protein levels (densitometry ...
近期本實驗室研究發現,長期餵食苦瓜之C57BL/6J小鼠,骨骼肌粒線體生合成相關基因Pgc1a,Nrf1,Tfam表現增加,並且體脂肪較少,個體能量消耗較高.因此本篇研究目標將以... 林家暐 - 《臺灣大學生化科技學系學位論文》 被引量: 0发表: 2015年 SIRT1/PGC-1α分子路径对於运动调控骨骼肌功能所扮演之角色 规律有氧运...
PGC-1α and its-regulated transcription factors including TFAM and NRF1, which are master regulators of mitochondrial biogenesis, are significantly downregulated in streptozotocin diabetic dorsal root ganglion (DRG) neurons. Diabetic mice develop peripheral neuropathy, loss of mitochondria, decreased ...
（3）SH-SY5Y细胞过表达PGC-1α可通过核呼吸因子1（nuclear respiratory factor, NRF1）影响线粒体的融合及自噬对MPP+造成的细胞损伤起保护作用。（4）C57BL/6小鼠黑质立体定位注射过表达PGC-1α慢病毒，可延长小鼠在转棒上运动的潜伏期，可以扭转MPTP造成的多巴胺能神经元的损伤，但同时也激活星形胶质细胞和小...