By applying western blot, it was found that hr5F alleviates the high glucose-induced superoxide overproduction insults by regulating SIRT1-PGC-1 alpha/Nrf2 pathway, together with regulating NRF-1, mtTFA, Bax/Bcl-2 to ameliorate cell apoptosis. The in vivo effects of hr5F on short term ...
Overexpression of GAS5 demonstrated protective effects against sepsis-induced renal injury via downregulating miR-579-3p and activating SIRT1/PGC-1alpha/Nrf2 pathway to inhibit cell pyroptosis. 展开 关键词: cell pyroptosis GAS5 miR-579-3p SIRT1 sepsis-associated renal injury ...
Vargas MR, Johnson DA, Sirkis DW, Messing A, Johnson JA: Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci 2008, 28: 13574–13581. 10.1523/JNEUROSCI.4099-08.2008 Article CAS PubMed PubMed Central Google Scholar ...
Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways. Gureev AP, Shaforostova EA, Popov VN. Front Genet. 2019 May 14;10:435. doi: 10.3389/fgene.2019.00435.You...
Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice 2019, Food and Function The therapeutic implications of tea polyphenols against dopamine (DA) neuron degeneration in parkinson’s disease (PD) 2019, Cells View all citing articles on Scopus ...
Anti-Nrf2核因子2相关因子2抗体Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related fact一抗Anti-NRG1/HRG beta 1乳腺癌细胞分化因子P45抗体 HeregulinβGGF2; Acetylcholine receptor inducing activity; ARIA; Breast cancer cell differentiation f一抗Anti-NRG3神经调节...
Nrf2 (NF-E2-related factor 2) and PGC1- 伪 (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha) regulate oxidative stress response in cells. Nrf-2 and PGC1-alpha double-knock-out (dKO) mice were used to monitor macro and morphological changes of eye, retina and retinal ...
We also found reduced mRNA expression levels of PKAC-alpha, CREB, PGC-1 alpha, NRF1, NRF2 and TFAM as early as 1 month-of-age, an age at which there was no significant A beta oligomer deposition, suggesting that mitochondrial biogenesis is likely impaired in ages preceding the development ...
ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial...Jonathan Z. LongJesse LouLi YeBruce M. SpiegelmanDiabetes
Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol. Ther. 2016, 157, 84–104. [Google Scholar] [CrossRef] [PubMed] Halling, J.F.; Pilegaard, H.J. PGC-1α-mediated regulation of mitochondrial function and physiological ...