Nrf2 pathwayprenatal stresspunicalaginScope Prenatal stress is closely associated with poor health outcomes for offspring, yet the specific mechanisms and effective interventions remain limited.Cao, KeLv, WeiqiangHu, ShaoqinGao, JingLiu, JiankangFeng, Zhihui...
We here describe that the expression of mitochondrial antioxidants and PGC-1α is markedly increased in inflammatory white matter lesions, particularly in reactive astrocytes. Overexpression of PGC-1α in human astrocytes reduced astrocytic ROS production and protects astrocytes from exogenous ROS-induced ...
By applying western blot, it was found that hr5F alleviates the high glucose-induced superoxide overproduction insults by regulating SIRT1-PGC-1 alpha/Nrf2 pathway, together with regulating NRF-1, mtTFA, Bax/Bcl-2 to ameliorate cell apoptosis. The in vivo effects of hr5F on short term ...
HU caused reduction of cross sectional area, redox status alteration (NRF2, SOD1 and catalase up-regulation), and induction of the ubiquitin proteasome system (MuRF-1 and atrogin-1 mRNA up-regulation) and autophagy (Beclin1 and p62 mRNA up-regulation). Trolox completely prevented the induction ...
NRF2 has been demonstrated to be an important regulatory factor of the inflammatory response. Peritoneal macrophages of NRF2-deficient mice exhibited the increased expression of binding activity genes of proinflammatory cytokines and NF-κB after administration of bacterial endotoxin. Numbers of natural ...
Exogenous ALA blocked oxidative stress by activating NRF2. Taken together, these findings demonstrate that exogenous ALA effectively prevents the progression of silicosis in a murine model, likely by stimulating mitochondrial biogenesis and endogenous antioxidant responses. Therefore, ALA can potentially delay...
Nrf2 (NF-E2-related factor 2) and PGC1- 伪 (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha) regulate oxidative stress response in cells. Nrf-2 and PGC1-alpha double-knock-out (dKO) mice were used to monitor macro and morphological changes of eye, retina and retinal ...
We also found reduced mRNA expression levels of PKAC-alpha, CREB, PGC-1 alpha, NRF1, NRF2 and TFAM as early as 1 month-of-age, an age at which there was no significant A beta oligomer deposition, suggesting that mitochondrial biogenesis is likely impaired in ages preceding the development ...