Nrf2 (NF-E2-related factor 2) and PGC1- 伪 (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha) regulate oxidative stress response in cells. Nrf-2 and PGC1-alpha double-knock-out (dKO) mice were used to monitor macro and morphological changes of eye, retina and retinal ...
Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways. Gureev AP, Shaforostova EA, Popov VN. Front Genet. 2019 May 14;10:435. doi: 10.3389/fgene.2019.00435.You...
GAS5 negatively and directly regulated miR-579-3p to reduce cell pyroptosis via the activation of SIRT1/PGC-1a/Nrf2 pathway. In addition, miR-579-3p suppressed PGC-1a/Nrf2 pathway to induce cell pyroptosis by directly targeting SIRT1. What's more, overexpression of GAS5, or knockdown of ...
Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice 2019, Food and Function The therapeutic implications of tea polyphenols against dopamine (DA) neuron degeneration in parkinson’s disease (PD) 2019, Cells View all citing articles on Scopus ...
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant e
Anti-Nrf2核因子2相关因子2抗体Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related fact一抗Anti-NRG1/HRG beta 1乳腺癌细胞分化因子P45抗体 HeregulinβGGF2; Acetylcholine receptor inducing activity; ARIA; Breast cancer cell differentiation f一抗Anti-NRG3神经调节...
We also found reduced mRNA expression levels of PKAC-alpha, CREB, PGC-1 alpha, NRF1, NRF2 and TFAM as early as 1 month-of-age, an age at which there was no significant A beta oligomer deposition, suggesting that mitochondrial biogenesis is likely impaired in ages preceding the development ...
ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial...Jonathan Z. LongJesse LouLi YeBruce M. SpiegelmanDiabetes
Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol. Ther. 2016, 157, 84–104. [Google Scholar] [CrossRef] [PubMed] Halling, J.F.; Pilegaard, H.J. PGC-1α-mediated regulation of mitochondrial function and physiological ...
response elements (ARES). NRF2 has been demonstrated to be an important regulatory factor of the inflammatory response. Peritoneal macrophages of NRF2-deficient mice exhibited the increased expression of binding activity genes of proinflammatory cytokines and NF-κB after administration of bacterial ...