在HepG2细胞中，预先用AKG处理可以显著提升线粒体中的PGC-1α、MFN2和Nrf2蛋白水平，同时轻微提高MFN1、NQO1和HO-1的水平，并明显抑制ACC和FASN的表达。为了深入探究，研究者利用siRNA进行转染实验，发现当PGC-1α被敲低后，AKG对T-CHO、TG和ROS的抑制效果显著减弱。进一步地，当同时敲低PGC-1α和Nrf2时，AKG...
PGC-1伪/Nrf2 signaling.Methods:An HFpEF model was established and subjected to CANA treatment.Blood pressure was monitored,and echocardiography was performed at the 12th week.Pathological examination was performed,and expression of ferroptosis-associated proteins and AMPK/PGC-1伪/Nrf2 signaling related ...
Nrf2 pathwayPrenatal stresspunicalaginScope : Prenatal stress is closely associated with poor health outcomes for offspring, yet the specific mechanisms and effective interventions remain limited. Methods and Results : In the present study, both male and female rat offspring exposed to prenatal restraint...
More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which...
The influence of phytochemicals on cancer cell metabolism via altering the AMPK/PGC-1α signaling pathway has not been thoroughly investigated in existing literature, and no previous reviews have been published in this area. The aim of this review is to explore the impact of phytochemicals on the...
PGC1 [alpha] drives a metabolic block on prostate cancer progression. Nat Cell Biol. 2016;18:589–90. Article CAS PubMed Google Scholar Vazquez F, Lim J-H, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM. PGC1α expression defines a subset...
因子β1(TGF-β1), 纤连蛋白(FN)和胶原蛋白Ⅰ(COLⅠ)表达变化;检测组织细胞膜电位变化和 ATP 酶含量明确线粒体损伤情况;Western blot 检测AMPK ,P-AMPK,PGC-1α,TFAM表达变化.结果 与DKD组相比,利格列汀治疗后,血糖水平(P<0.01),蛋白尿(P<0.05)显 著降低,肾脏病理,超微结构损伤明显减轻,TGF-β1,FN,...
NAD+, decreased ADP and AMP contents and the ratio of AMP/ATP, reduced the level of ROS and MDA, enhanced SOD activity, evidently increased the levels of AMPK, SIRT1 and PGC-1 alpha mRNA, up-regulated the expressions of AMPK, pAMPK, SIRT1, PGC-1alpha, NRF1, TFAM and FOXO1 proteins...
When cardiomyocyte oxygen is reduced, AMPK is activated by elevated concentrations of AMP and directly regulates the expression of SIRT5 and PGC-1α. PGC-1α then coactivates many nuclear factors, such as PPARα, ERRα and NRF2. PPAR-α interacts with NRF2 in the transcription of nuclear ...
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1alpha/Sirt3. J Hazard Mater. 2022;437:129381. Article CAS PubMed Google Scholar Yang L, Wang B, Guo F, Huang R, Liang Y, Li L, et al....