在HepG2细胞中，预先用AKG处理可以显著提升线粒体中的PGC-1α、MFN2和Nrf2蛋白水平，同时轻微提高MFN1、NQO1和HO-1的水平，并明显抑制ACC和FASN的表达。为了深入探究，研究者利用siRNA进行转染实验，发现当PGC-1α被敲低后，AKG对T-CHO、TG和ROS的抑制效果显著减弱。进一步地，当同时敲低PGC-1α和Nrf2时，AKG...
More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which...
因子β1(TGF-β1), 纤连蛋白(FN)和胶原蛋白Ⅰ(COLⅠ)表达变化;检测组织细胞膜电位变化和 ATP 酶含量明确线粒体损伤情况;Western blot 检测AMPK ,P-AMPK,PGC-1α,TFAM表达变化.结果 与DKD组相比,利格列汀治疗后,血糖水平(P<0.01),蛋白尿(P<0.05)显 著降低,肾脏病理,超微结构损伤明显减轻,TGF-β1,FN,...
研究表明,线粒体生物发生始于多个细胞核分子事件,其中过氧化物酶体增殖物活化受体γ辅激活蛋白-1α(peroxisome proliferator-activated receptor gamma coactivator-1 alpha, PGC-1α)是目前已知调控线粒体生物发生最为关键的转录因子。在细胞核内,PGC-1α与转录因子相互作用,辅激活核呼吸因子2(nuclear respiratory fac...
The influence of phytochemicals on cancer cell metabolism via altering the AMPK/PGC-1α signaling pathway has not been thoroughly investigated in existing literature, and no previous reviews have been published in this area. The aim of this review is to explore the impact of phytochemicals on the...
Anthocyanins are able to improve the symptoms of NASH in mice receiving a methionine-choline-deficient (MCD) diet by activating the AMPK/PGC-1α signaling pathways. Meanwhile, anthocyanins suppress HSC activation and α-SMA and collagen I production in the NASH mouse, which is concomitant with a...
Although the mechanisms underlying AMPK-induced inhibition of NFκB are not clearly understood, multiple mechanisms that suppress the expression of inflammatory genes, including activation of SIRT1, FOXO and PGC1α, may be involved.117 Interestingly, emerging evidence suggests that AMPK exerts anti-...
SIRT6过表达激活AMPK/Nrf2/HO-1通路抑制AngⅡ诱导的心肌细胞凋亡 [目的]探讨沉默调节蛋白6(SIRT6)过表达抑制血管紧张素Ⅱ(AngⅡ)诱导的心肌细胞凋亡是否涉及腺苷酸活化蛋白激酶/核因子E2相关因子2/血红素加氧酶1(AMPK/Nrf2/HO-1)信号... 卢振华,沈静,黄文军,... - 《中国动脉硬化杂志》 被引量: 0发表: ...
N-myristoyl transferase 1 NRF2: Nuclear factor erythroid 2-related factor 2 PAQR3: Progestin and adipo-Q receptor 3 PGC1α: PPARγ coactivator 1α PI3P: Phosphatidylinositol 3-phosphate PIK3C3: Phosphatidylinositol 3-kinase catalytic subunit 3 PIK3R4: Phosphoinositide 3-kinase regulatory ...
Adipose tissue-derived adipokines facilitate inter-organ communication between adipose tissue and other organs. Omentin-1, an adipokine, has been implicated in the regulation of glucose and insulin metabolism. However, limited knowledge exists regarding