Our results demonstrate that FUNDC1-dependent mitophagy is directly coupled with mitochondrial biogenesis through the PGC-1 alpha/NRF1 pathway, which dictates mitochondrial quantity, quality, and turnover and contributes to adaptive thermogenesis.
NAD+, decreased ADP and AMP contents and the ratio of AMP/ATP, reduced the level of ROS and MDA, enhanced SOD activity, evidently increased the levels of AMPK, SIRT1 and PGC-1 alpha mRNA, up-regulated the expressions of AMPK, pAMPK, SIRT1, PGC-1alpha, NRF1, TFAM and FOXO1 proteins...
EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breastcancer The EglN2/PHD1 prolyl hydroxylase is an important oxygen sensor contributing to breast tumorigenesis. Emerging studies suggest that there is functional cro... J Zhang,C Wang,X Chen,... - 《Embo ...
摘要: Following its activation by PINK1, parkin is recru 关键词:autophagy mitochondria parkin Parkinson's PGC1 alpha TFEB 被引量: 35 年份: 2015 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 ResearchGate (全网免费下载) jneurosci.org (全网免费下载) jneurosci.org (全网免费下载) ...
Our study demonstrated that the protein expression pattern of the transcription factor pCREB/CREB, together with the protein expression of PGC-1 alpha, NRF1 and TFAM are all significantly reduced in early ages of 3xTg-AD mice. We also found reduced mRNA expression levels of PKAC-alpha, CREB,...
MFG-E8 could upregulate the phosphorylation level of Akt and ERK via activating Akt/Sirt1/PGC-1 alpha and MAPK/ERK signaling pathway cascades in L6 cells, and promote the mitochondrial biogenesis of L6 cells, thereby upregulating the mRNA expression of NDUFA9, SDHA, UQCRC2, ATP5a, Nrf1, ...
ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial...Jonathan Z. LongJesse LouLi YeBruce M. SpiegelmanDiabetes
Our data indicate that exposure to ropivacaine leads to reduced expression of the major mitochondrial regulator PGC-1 alpha and its downstream transcription factors NRF1 and TFAM. Ropivacaine treatment induces impairment of mitochondrial biogenesis by reducing mitochondrial mass, the ratio of mtDNA to n...
There was no significant change in sirtuin 1 or NRF1 expression. Similarly, P. aeruginosa infection attenuated expression of PGC-1α and SIRT3 in primary human bronchial epithelial cells (Figure 2B). Next, we investigated whether P. aeruginosa infection resulted in downregulation of important ...
The redox system is closely related to changes in cellular metabolism. Regulating immune cell metabolism and preventing abnormal activation by adding antioxidants may become an effective treatment for oxidative stress and inflammation-related diseases. Q