NRF1 binds to the classic consensus site in the promoter of Fundc1 to upregulate its expression and to enhance mitophagy through its interaction with LC3. Specific knockout of Fundc1 in BAT results in reduced mitochondrial turnover and accumulation of functionally compromised mitochondria, leading to...
NAD+, decreased ADP and AMP contents and the ratio of AMP/ATP, reduced the level of ROS and MDA, enhanced SOD activity, evidently increased the levels of AMPK, SIRT1 and PGC-1 alpha mRNA, up-regulated the expressions of AMPK, pAMPK, SIRT1, PGC-1alpha, NRF1, TFAM and FOXO1 proteins...
EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breastcancer The EglN2/PHD1 prolyl hydroxylase is an important oxygen sensor contributing to breast tumorigenesis. Emerging studies suggest that there is functional cro... J Zhang,C Wang,X Chen,... - 《Embo ...
Our study demonstrated that the protein expression pattern of the transcription factor pCREB/CREB, together with the protein expression of PGC-1 alpha, NRF1 and TFAM are all significantly reduced in early ages of 3xTg-AD mice. We also found reduced mRNA expression levels of PKAC-alpha, CREB,...
ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial...Jonathan Z. LongJesse LouLi YeBruce M. SpiegelmanDiabetes
MFG-E8 could upregulate the phosphorylation level of Akt and ERK via activating Akt/Sirt1/PGC-1 alpha and MAPK/ERK signaling pathway cascades in L6 cells, and promote the mitochondrial biogenesis of L6 cells, thereby upregulating the mRNA expression of NDUFA9, SDHA, UQCRC2, ATP5a, Nrf1, ...
Our data indicate that exposure to ropivacaine leads to reduced expression of the major mitochondrial regulator PGC-1 alpha and its downstream transcription factors NRF1 and TFAM. Ropivacaine treatment induces impairment of mitochondrial biogenesis by reducing mitochondrial mass, the ratio of mtDNA to n...
The redox system is closely related to changes in cellular metabolism. Regulating immune cell metabolism and preventing abnormal activation by adding antioxidants may become an effective treatment for oxidative stress and inflammation-related diseases. Q
Relative mRNA expression of TFAM, SIRT1, SIRT3, NRF1, and NRF2 were measured from left lung homogenates. N = 6. PAO1 infection attenuates expression of several genes involved in mitochondrial quality control both in vitro in bronchial epithelial cells and in the lungs in a murine pneumonia ...