activator 1 alpha (PGC-1α) could control the signaling pathway of both NFE2L2 and GABPA through distinct molecular mechanisms. This review will summarize the implications of NFE2L2 and GABPA in various human patho-physiological conditions and how PGC-1α can regulate their different signaling...
PGC-1α peroxisomeproliferator-activatedreceptor gammacoactivator1alpha 过氧化物酶体增殖物激活 受体γ辅激活因子1α PMSFphenylmethylsulfonylfluoride苯甲基磺酰氟化物 PPARγ Peroxisomeproliferator-activatedreceptor gamma 过氧化物酶体增殖物激活 受体γ
雌激素在蜕膜化过程中也不可或缺,雌二醇对PR表达起到重要作用,且研究表明在PR阳性的ESC中,靶向消融雌激素受体-α(estrogen receptor alpha,ER-α)会导致蜕膜化诱导失败[50]。有研究证实Nrf2与雌激素之间也存在密切联系[51]。雌激素会增强Nrf2的表...
Additionally, it maintains the integrity of bone microstructure and calcium homeostasis by activating Nrf2/GSK-3β signaling and increasing the expression of PGC-1α and TFAM [127]. Increased oxidative stress is a key factor in the progression of osteoporosis due to estrogen deficiency. Estrogen ...
5.Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005; 434:113–18.https://doi.org/10.1038/nature03354[PubMed] 6.Davoren JB, Kasson BG, Li CH, Hsueh AJ. Specific insuli...
Blots were probed for Complex I (CI) subunit NDUFB8, Complex II (CII) subunit SDHB, Complex III (CIII) subunit UQCRC2, Complex IV (CIV) subunit COX II, Complex V (CV) ATP synthase subunit alpha, as well as actin (upper). Bar graph depicts quantification of the abundance of each ...
More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which...
Overexpression of GAS5 demonstrated protective effects against sepsis-induced renal injury via downregulating miR-579-3p and activating SIRT1/PGC-1alpha/Nrf2 pathway to inhibit cell pyroptosis. 展开 关键词: cell pyroptosis GAS5 miR-579-3p SIRT1 sepsis-associated renal injury ...
alpha-Tubulin (1:10000) Sigma-Aldrich Cat#T6074-200UL; RRID: AB_477582 Cul1 (1:1000) Thermo Fisher Scientific Cat#718700; RRID: AB_2534002 HA (1:1000) Sigma-Aldrich Cat#H3663; RRID: AB_262051 Flag (1:4000) Sigma-Aldrich Cat#F1804; RRID: AB_262044 Biological Samples Human Tissue ...
Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. J Pharmacol Sci. 2019;139(4):352–60. Article CAS PubMed Google Scholar Bellezza I, Giambanco I, Minelli A,...