Additionally, it maintains the integrity of bone microstructure and calcium homeostasis by activating Nrf2/GSK-3β signaling and increasing the expression of PGC-1α and TFAM [127]. Increased oxidative stress is a key factor in the progression of osteoporosis due to estrogen deficiency. Estrogen ...
activator 1 alpha (PGC-1α) could control the signaling pathway of both NFE2L2 and GABPA through distinct molecular mechanisms. This review will summarize the implications of NFE2L2 and GABPA in various human patho-physiological conditions and how PGC-1α can regulate their different signaling...
Pten-induced kinase 1 PGC-1α: Proliferator-activated receptor gamma coactivator-1 alpha PPP: Pentose phosphate pathway QDs: Quantum dots ROS: Reactive oxygen Species RNS: Reactive nitrogen species SNpc: Substantia nigra pars compacta SRXN1: Sulfiredoxin-1 SOD2: Superoxide dismutase 2 SQSTM1: Se...
The effects of Nrf2-KD on meiotic progression prompted us to consider the possible target in mouse oocytes. Therefore, we further analyzed the expression of Cyclin B1 and Cyclin-dependent kinase 1 (CDK1) by qPCR and western blot analysis. The qPCR results shown inFig. 4Cindicated declined Cycl...
雌激素在蜕膜化过程中也不可或缺,雌二醇对PR表达起到重要作用,且研究表明在PR阳性的ESC中,靶向消融雌激素受体-α(estrogen receptor alpha,ER-α)会导致蜕膜化诱导失败[50]。有研究证实Nrf2与雌激素之间也存在密切联系[51]。雌激素会增强Nrf2的表...
More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which...
PGC1α: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha PH: Pleckstrin homology PI3K: Phosphatidylinositol-3 kinases Pin1: Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 PINK1: PTEN-induced kinase 1 PKB: Protein kinase B PSD95: Postsynaptic density protein 95 PT...
Blots were probed for Complex I (CI) subunit NDUFB8, Complex II (CII) subunit SDHB, Complex III (CIII) subunit UQCRC2, Complex IV (CIV) subunit COX II, Complex V (CV) ATP synthase subunit alpha, as well as actin (upper). Bar graph depicts quantification of the abundance of each ...
1 inhibitor Znpp, which subsequently reduced cell viability, increased the levels of apoptotic factors such as Bax and caspase-3, and decreased the levels of mitochondrial biogenesis-related proteins such as PGC1-α. Isoliquiritigenin may therefore be an efficacious treatment for RA, acting to ...
As a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) has been found to be declined in aged C57BL/6J mice (Wiedmer et al., 2021; Yeo et al., 2019). PGC-1α can modulate the complex mitochondrial function, including...