Additionally, it maintains the integrity of bone microstructure and calcium homeostasis by activating Nrf2/GSK-3β signaling and increasing the expression of PGC-1α and TFAM [127]. Increased oxidative stress is a key factor in the progression of osteoporosis due to estrogen deficiency. Estrogen ...
activator 1 alpha (PGC-1α) could control the signaling pathway of both NFE2L2 and GABPA through distinct molecular mechanisms. This review will summarize the implications of NFE2L2 and GABPA in various human patho-physiological conditions and how PGC-1α can regulate their different signaling...
Pten-induced kinase 1 PGC-1α: Proliferator-activated receptor gamma coactivator-1 alpha PPP: Pentose phosphate pathway QDs: Quantum dots ROS: Reactive oxygen Species RNS: Reactive nitrogen species SNpc: Substantia nigra pars compacta SRXN1: Sulfiredoxin-1 SOD2: Superoxide dismutase 2 SQSTM1: Se...
雌激素在蜕膜化过程中也不可或缺,雌二醇对PR表达起到重要作用,且研究表明在PR阳性的ESC中,靶向消融雌激素受体-α(estrogen receptor alpha,ER-α)会导致蜕膜化诱导失败[50]。有研究证实Nrf2与雌激素之间也存在密切联系[51]。雌激素会增强Nrf2的表...
Blots were probed for Complex I (CI) subunit NDUFB8, Complex II (CII) subunit SDHB, Complex III (CIII) subunit UQCRC2, Complex IV (CIV) subunit COX II, Complex V (CV) ATP synthase subunit alpha, as well as actin (upper). Bar graph depicts quantification of the abundance of each ...
5.Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005; 434:113–18.https://doi.org/10.1038/nature03354[PubMed] 6.Davoren JB, Kasson BG, Li CH, Hsueh AJ. Specific insuli...
PGC1α: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha PH: Pleckstrin homology PI3K: Phosphatidylinositol-3 kinases Pin1: Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 PINK1: PTEN-induced kinase 1 PKB: Protein kinase B PSD95: Postsynaptic density protein 95 PT...
More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which...
Here, we aimed to analyze the effects of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) on mitochondrial reactive oxygen species (ROS) and nuclear factor erythroid 2-related factor 2 (Nrf2) in aged skeletal muscles. Methods C2C12 cells were stimulated by 50 μM ...
alpha-Tubulin (1:10000) Sigma-Aldrich Cat#T6074-200UL; RRID: AB_477582 Cul1 (1:1000) Thermo Fisher Scientific Cat#718700; RRID: AB_2534002 HA (1:1000) Sigma-Aldrich Cat#H3663; RRID: AB_262051 Flag (1:4000) Sigma-Aldrich Cat#F1804; RRID: AB_262044 Biological Samples Human Tissue ...