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Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women There was an advantage to treatment with AIs in terms of progression-free survival (HR 0.78, 95% CI 0.70 to 0.86) and clinical benefit (OR 0.70, ... LJ Gibson,CK Dawson,DH Lawrence,... - 《Cochrane Databa...
Also found in: Dictionary, Thesaurus, Medical. Related to Folex PFS: methotrexate sodiummethotrexate methotrexate, drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemia, psoriasis, and non-Hodgkin's lymphoma. By binding...
In terms of safety, 91% of patients in the experimental arm and 66% of patients in the control arm had grade 3/4 AEs. This was most notably in hematologic toxic events. The rate of grade 3/4 thrombocytopenia was 59% in the experimental arm and 39% in the control arm. Additionally, ...
Marc Ernstoff, MD, director of melanoma, Cleveland Clinic, discusses progression-free survival (PFS) and safety in patients with advanced melanoma (MEL) receiving nivolumab (NIVO) combined with ipilimumab (IPI). Ernstoff describes the 2:1 randomization of this phase II study. He mentions that...
A systematic review and meta-analysis of randomized studies has shown a significant benefit with single ASCT in terms of prolonged progression-free survival (PFS), but not of overall survival (OS). In our retrospective analysis we investigated the impact of high dose (HD) chemotherapy followed ...
Recycling the fuel costs far less than disposing of it and sourcing more, not just in monitory terms but also in terms of carbon emissions, said Ross. We did one hospital in Gloucester that had spent £750,000 on fuel for its back-up generators, so this is no small amount we are ta...
2022, Journal of Clinical Oncology Olaparib as maintenance treatment for patients with platinum-sensitive relapsed ovarian cancer 2019, Therapeutic Advances in Medical Oncology View all citing articles on Scopus † Present address: Department of Mathematical Sciences, University of Bath, Bath, UK. ...
In terms of safety, researchers observed grade 3 or higher treatment-associated adverse events among 74% of patients assigned sacituzumab govitecan vs. 60% of those assigned physician’s choice of treatment. The most common included neutropenia (51% vs. 38%) and diarr...
We hope that toripalimab will provide better treatment options for patients and address unmet medical needs.” References Junshi Biosciences announces toripalimab in combination with chemotherapy for treatment of advanced triple-negative breast cancer met primary endpoint in phase 3 clinical study. News...