“The results showed a dramatic increase in PFS. There was a 55% reduction in the risk of progression compared with chemotherapy, which is somewhat unprecedented,” Powles, the director of Barts Cancer Centre at St Bartholomew’s Hospital in London, England, said in an interview with Oncology ...
The method has been successfully used in characterisation and detection of brain and prostate cancer and there is some evidence towards its use as a response biomarker following chemotherapy in breast cancer (Baek et al, 2009). There is yet not enough evidence to support the role of MRS as a...
T-VEC is currently being evaluated as a potential treatment in melanoma and other advanced cancers [19, 20]. In a pre-clinical study in breast cancer bearing mice, the combination of an anti-PD1 antibody and a multi-peptide vaccine prolonged the vaccine-induced progression-free survival (PFS)...
As orphan drugs are considered an exception in class 1 (i.e. drug with an added value), a budgetary impact study is required in the reimbursement dossier but a cost-effectiveness analysis is not. The DRC is composed of one (non-voting) chairman and 30 members; 22 voting members (i.e....
Platinum-based chemotherapy is standard treatment for non-small cell lung cancer (NSCLC), but in the expanding world of tyrosine kinase inhibitors established regimes are being questioned. Ramalingham et al (J Clin Oncol 2015;33:433–41) have published a Phase II randomised, double-blind, place...
A single-arm, multicenter, safety-monitoring, phase IV study of icotinib in treating advanced non-small cell lung cancer (NSCLC) The phase 3 ICOGEN trial established the non-inferiority of icotinib to gefitinib in terms of progression-free survival (PFS) in non-small cell lung cancer... X ...
In 80% of cases, HCC arises in patients with cirrhosis with previous hepatitis B and C infection or alcoholics and it is the most widespread primary liver cancer [1,2]. In cirrhotic liver, HCC shows hyperenhancement of the arterial phase, followed by a delayed portal or venous phase ...
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). 1. Introduction 1.1. "Chemotherapy" in the 21st Century The landscape of systemic anticancer therapy (SACT) ...
In terms of limitations, the study only included cancer patients who received less than four points on the ECOG scale and were treated at a single private facility. The Effect of Health Literacy on Self-Efficacy and Quality of Life among Turkish Cancer Patients AAP: abiraterone acetate plus pred...
In this context indoleamine 2,3-dioxygenase 1 (IDO1) is one of the most studied target of cancer immunotherapies by virtue of its effects on immune suppression in the TME[6]. IDO1, a monomeric heme-containing enzyme, is one of the three enzymes that catalyze the first and rate-limiting ...