The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which leads to bone pain, pathological fractures, spinal...
27]. This complicated crosstalk allows for the normal functioning of immune tolerance and immunosurveillance, which recognizes and eliminates opportunistic bacteria to prevent potential infection. The critical role of the gut microbiota in the formation of a fully functional immune system...
In a phase I/II vaccination clinical trial using a personalized DCleu vaccine with patient-derived AML cells fused with autologous dendritic cells, among the 17 participating AML patients, 12 demonstrated durable expansion of leukemia-specific T cells. Despite a median age of 63 years, 71% of p...
Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most common hematological malignancies worldwide. Despite the advances in the treatment of patients with NHLs, relapse or resistance to treatment is anticipated in several patients. Therefore, novel therapeutic approaches are needed. Rece...
In another phase II study of MLN8237 in advanced/metastatic sarcoma, occasional responses and prolonged stable disease were observed, and progression-free survival (PFS) was promising [150]. In castration-resistant neuroendocrine prostate cancer patients, those with AURKA and N-myc activation achieve ...
(PFS) (Log-rank testP < 0.0001 for the Gide anti-PD-1 cohort andP < 0.0001 for the Gide anti-CTLA-4 cohort; Fig.6a). Next, we divided the melanoma patients into high and low iCAF score groups based on the median and compared the percentage of ICB responders between the ...
(PFS) (24 vs 12.5 months, HR = 0.67, 95%CI, 0.48–0.94), and a significant decrease in the rate of extrahepatic metastasis, which could alleviate the side effects of patients to some extent [129]. The study found that the rate of 3-year OS of the Chaihu-Huaji Decoction ...
review of the first 60 patients randomized to the two experimental arms (90 patients randomized total). The primary endpoint of the trial is progression free survival (PFS) by blinded independent central review (BICR), with secondary endpoints of overall survival (OS) and overall response...
In addition, Kaplan-Meier survival analysis showed that NPC patients with high FLI1 expression levels had a remarkably shorter overall survival (OS, p = 0.030), local recurrence free survival (LRFS, p = 0.010) and progress free survival (PFS, p = 0.021) (Fig. 1C–E). ...
Claudins (CLDNs) are a family of proteins and are important components of tight junctions (TJs) [1], which form a paracellular barrier to control the flow of molecules between cells. CLDNs have transmembrane domains and an N-terminus and a C-terminus in the cytoplasm (Fig. 1). Different...