重组PF4蛋白以CXCR3依赖的方式诱导TH1-Treg细胞极化。PF4还增强了TH1-Treg细胞的抑制功能,并且发现其在Arg1+ TAMs中特异性高表达。此外,IFN-γ参与了Treg细胞上CXCR3的初始表达,PF4进一步增强了TH1-Treg细胞极化。TME中PF4的主要来源是Arg1+ TAMs,因为它们比产生CXCL9的cDC1s更为丰富。 作者构建了Pf4−/−小鼠...
提示PF4对老年小鼠大脑的有益作用涉及循环系统中抗衰老免疫因子水平的降低和衰老外周免疫系统的恢复。进一步机制研究发现,趋化因子受体CXCR3可能介导PF4发挥大脑抗衰老功效。综上,该研究揭示了血小板衍生PF4减轻衰老相关的大脑炎症能力,具有挽救老...
之前的工作指出趋化因子受体CXCR3主要介导PF4发挥作用【2, 3】,但公开可用数据表明CXCR3几乎只表达于外周髓系和淋巴细胞群。为了确认CXCR3作为PF4对衰老海马有益影响的可能中介。作者给老年Cxcr3-KO小鼠注射PF4或生理盐水并评估对海马神经炎症、转录变化和认知功能的影响,结果显示 CXCR3的缺失会消除突触可塑性相关标记...
作者给老年Cxcr3-KO小鼠注射PF4或生理盐水并评估对海马神经炎症、转录变化和认知功能的影响,结果显示 CXCR3的缺失会消除突触可塑性相关标记物(Lgi1和Neurod1)的表达,而PF4处理可引起促炎基因表达水平降低,三项行为学测试也显示出一定程度上的改善。 综上所述,这项工作表明血小板衍生的趋化因子PF4是一种促年轻因子,...
liver-specific alteration.The abnormal accumulation of MDSCs was found in β-catenin-activating orthotopic HCC models.PF4 as a downstream target of β-catenin was essential for β-catenin-mediated MDSC accumulation.PF4 receptor CXCR3 was responsible for the recruitment of MDSCs by PF4 and β-...
fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of ...
and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin.PF4 autoantibodies have also been found in patients with thrombosis and...
CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation...
技术支持 货号PA5-79809 CNY2,877.00 100 µg 下单后预计有货时间 14-Apr-2025 查看价格 批量或定制请求 抗体检测数据 (1) Application Created with Sketch. 图:1/1 PF4 Antibody (PA5-79809) in WB Western blot analysis of PF4 in 293T whole cell lysate (lane 1) and A549 whole cell lysate ...
chemokine activity heparin binding CXCR3 chemokine receptor binding molecular_function CXCR chemokine receptor binding chemokine 参与通路 platelet degranulation positive regulation of leukocyte chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway positive regulation of gene...