将Pf4-Cre小鼠Q3品系与ROSA26-lacZ报告品系杂交,结果表明cre -重组酶的活性仅限于巨核细胞。该品系代表了产生巨核细胞谱系限制特异性靶向突变体的有效工具。 Tiedt R , et al. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.
cre鼠就是我们常用的带有不同的cre酶的工具鼠统称可用于繁育交配比如说b6129p2lyz2tm1crelfonju这种就是我们的带有骨髓细胞特异表达cre酶的模型还有很多很多在不同组织表达的酶的模型可以根据自己的实验需求来安排 PF4-creERT2小鼠是什么? 展开全文 什么是cre鼠?cre鼠就是我们常用的带有不同的cre酶的工具鼠统称,...
In this issue of Blood, Nagy et al developed a novel Gp1ba-Cre mouse that uses the endogenous Gp1ba locus that encodes the glycoprotein Iba (GPIba) subunit of the GPib-IX receptor to drive Cre expression in murine megakaryocytes (MKs) for targeted ablation of floxed genes....
医学/心理学 > 临床医学 > 谱系追踪pf4-cre 下载文档 收藏 打印 转格式 532阅读文档大小:3.12M12页zhouhai623上传于2013-03-30格式:PDF 1PF2G2-4X齿轮泵资料 热度: 2-CRE06-C701快运包裹运输规则D2 热度: 细胞谱系追踪技术-剖析洞察 热度: FibroblastGrowthFactorReceptor-MediatedActivation ...
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Comparison of Pf4-Cre(neg);α2flox/flox mice (f/f), heterozygous Pf4-Cre(neg);α2+/flox mice (f/−) and α2-cKO mice (−/−).David, HabartYann, CheliDiane, J. NugentZaverio, M. RuggeriThomas, J. Kunicki
Finally, we show for the first time that Pf4 transcripts are present in adult HSCs and primitive hematopoietic progenitor cells. These results have fundamental implications for the use of the Pf4-Cre mouse model and for our understanding of a possible role for Pf4 in the development of the ...
Pf4-Cre activates RFP expression in all hematopoietic lineages.Simon D. J. CalaminusAmelie GuitartAmy SinclairHannah SchachtnerSteve P. WatsonTessa L. HolyoakeKamil R. KrancLaura M. Machesky
However, Pf4-ΔCre displays ectopic expression outside the megakaryocyte/platelet lineage, especially during inflammation. The use of the Gp1ba (glycoprotein 1bα) Cre promises a more specific, targeted approach. To evaluate the role of Cox-1 in platelets, we crossed Pf4-ΔCre or Gp1ba-ΔCre...