提示PF4对老年小鼠大脑的有益作用涉及循环系统中抗衰老免疫因子水平的降低和衰老外周免疫系统的恢复。进一步机制研究发现,趋化因子受体CXCR3可能介导PF4发挥大脑抗衰老功效。综上,该研究揭示了血小板衍生PF4减轻衰老相关的大脑炎症能力,具有挽救老...
作者给老年Cxcr3-KO小鼠注射PF4或生理盐水并评估对海马神经炎症、转录变化和认知功能的影响,结果显示 CXCR3的缺失会消除突触可塑性相关标记物(Lgi1和Neurod1)的表达,而PF4处理可引起促炎基因表达水平降低,三项行为学测试也显示出一定程度上的改善。 综上所述,这项工作表明血小板衍生的趋化因子PF4是一种促年轻因子,...
之前的工作指出趋化因子受体CXCR3主要介导PF4发挥作用【2, 3】,但公开可用数据表明CXCR3几乎只表达于外周髓系和淋巴细胞群。为了确认CXCR3作为PF4对衰老海马有益影响的可能中介。作者给老年Cxcr3-KO小鼠注射PF4或生理盐水并评估对海马神经炎症、转录变化和认知功能的影响,结果显示 CXCR3的缺失会消除突触可塑性相关标记...
known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity ...
Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of ...
it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in hepa...
说明书 实验方案 技术支持 货号PA5-79809 CNY2,877.00 100 µg 下单后预计有货时间 14-Apr-2025 查看价格 批量或定制请求 抗体检测数据 (1) Application Created with Sketch. 图:1/1 PF4 Antibody (PA5-79809) in WB Western blot analysis of PF4 in 293T whole cell lysate (lane 1) and A549 who...
chemokine activity heparin binding CXCR3 chemokine receptor binding molecular_function CXCR chemokine receptor binding chemokine 参与通路 platelet degranulation positive regulation of leukocyte chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway positive regulation of gene...
Mechanistically, we identified CXCR3 and LDLR as the HSC receptors transmitting the PF4 signal. Finally, our results further indicate that phenotypic human HSCs are also responsive to the PF4 youthful signal. Altogether, our findings contribute to the development of targeted therapies for stem cell ...
An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Recep... The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and...