Despite high expectations, the peptide-based vaccines that have been explored in the clinic so far had limited therapeutic activity, largely due to cancer cell-intrinsic alterations that minimize antigenicity and/or changes in the tumor microenvironment that foster immunosuppression. Several strategies ...
Unlike mAbs or chemotherapy, TAA-based vaccines which induce the immune system to produce patients’ own antibodies toward the antigen may prevent the development or reduce the intensity of hypersensitivity reactions, can induce prolonged activation of the immune system, immunological memory, and ...
Peptide-based vaccines Nanovaccine Delivery system Nanomaterials Immune response 1. Introduction Peptide-based vaccines often contain only key amino acid sequences of tumor neoantigens, pathogen or protein antigens, therefore can provide precise activation of immune responses and have great potential for ...
These findings demonstrate the potential of peptide-based vaccines against tuberculosis and indicate that there is not direct correlation between the hierarchy ... AW Olsen,PR Hansen,A Holm,... - 《European Journal of Immunology》 被引量: 505发表: 2000年 ...
Peptide-based vaccines for cancer: are we choosing the right peptides? Recently, immunotherapy has emerged as a treatment strategy in the adjuvant setting of breast cancer. In this review, monoclonal antibodies in passive and ... Vasso,Apostolopoulos - 《Expert Review of Vaccines》 被引量: 32...
Peptide-Based Cancer VaccinesW Martin Kast . 2002 Macmillan Publishers Limiteddoi:10.1038/sj.leu.2402436RK BrightLeukemiaBright RK, Franz RW. Book review. Peptide-based cancer vaccines. Leukemia. 2002;16:970–1. : 10.1038/sj/leu/2402436 ....
Lipopeptides derived from bacterial cell wall components including lipoproteins, peptidogly- cans, lipoteichoic acid and lipopolysaccharides can 9.1.4 PamnCys Ligand as Adjuvant for Peptide-Based Vaccines activate Toll-like receptor 2 (TLR2) (Basto and Leitao 2014; Zaman and Toth 2013). ...
However, so far, no PCSK9 peptide vaccines containing unnatural/modified amino acids have been reported and also no significant attempts have been made to improve the metabolic stability of these PCSK9 peptides, using suitable chemical modifications so as to improve its efficacy and/or potency alon...
Peptide-based vaccines for cancer: are we choosing the right peptides? Recently, immunotherapy has emerged as a treatment strategy in the adjuvant setting of breast cancer. In this review, monoclonal antibodies in passive and ... Vasso,Apostolopoulos - 《Expert Review of Vaccines》 被引量: 32...
find many applications in the development of peptide-based vaccines or as potential therapeutic agents in the treatment of allergies and autoimmune diseases.do... Guichard,G Connan,F Graff,... - 《Journal of Medicinal Chemistry》 被引量: 141发表: 1996年 Peptide-based immunotherapy: A novel stra...