Peptide-based vaccines for cancerAdvances in the engineering of peptides, adjuvants and delivery systems have renewed the enthusiasm for peptide-based vaccination regimens in the setting of cancer, and there are a variety of clinical trials being conducted by pharmaceutical companies based on the use...
Peptide-based vaccines for cancer: are we choosing the right peptides? Recently, immunotherapy has emerged as a treatment strategy in the adjuvant setting of breast cancer. In this review, monoclonal antibodies in passive and ... Vasso,Apostolopoulos - 《Expert Review of Vaccines》 被引量: 32...
Multi-disciplinary approaches paving the way for clinically effective peptide vaccines for cancer Bansari A. Shah James A. Holden Neil M. O’Brien-Simpson ReviewsOpen Access09 Apr 2025npj Vaccines Volume: 10, P: 68 Design and evaluation of a poly-epitope based vaccine for the induction of infl...
(c) Screening of Highly Immunogenic Peptides: Screening peptides to identify those with high immunogenicity for the efficacy of personalized DNA-based cancer vaccines (PCV). (d) Neoantigen Peptide Delivery: Developing efficient delivery systems to ensure the peptides reach their intended targets within...
Peptide vaccination for breast cancer aims to elicit a tumor-specific active immune response, with simple administration and limited toxicity. Despite promising immunologic data, clinical results continue to be mixed. Principles of cancer vaccine develop
The present status and future prospects of peptide-based cancer vaccines. Int. Immunol. 28, 319–328 (2016). Article CAS PubMed Google Scholar Chen, X., Yang, J., Wang, L. & Liu, B. Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives...
Peptide vaccines are cost-effective compared to other vaccine approaches, and effective epitopes eliciting strong immune response can be selected experimentally in silico and ex vivo. However, the clinical benefits of cancer peptides vaccine have been disappointing in most studies; therefore, we need ...
Department of Hematology and Oncology, Winship Cancer Institute, Emory University, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA;Springer USCurrent Colorectal Cancer ReportsWalid Shaib, Daniel Goldstein, Bassel F. El-Rayes. (2014) Peptide Vaccines for Treatment of Colon Cancer: Have We Made ...
This review primarily focuses on the significant advances made in the use of synthetic peptides in the development of subunit cancer vaccines. We have attempted to highlight some of the fundamental issues regarding antigen processing and presentation, Major Histocompatibility Complex (MHC) restriction, ...
Immune Correlates of Vaccine Adjuvanticity, Immunogenicity and Efficacy in Infectious Diseases and Cancer. 2.2.3Personalized peptide vaccines based on pre-existing immunity A series of trials have been performed with so-called personalized peptidevaccination(PPV). Here, vaccine-peptides are selected from...