Classical whole-organism vaccines may have several pitfalls such as the potential risk of inducing autoimmune and/or allergic responses. Synthetic peptide-based vaccines are an alternative solution to overcome the disadvantages associated with classical vaccines. Peptide-based vaccines are built of defined...
Peptide‑Based Vaccines for COVID‑19 Peptide-based vaccines (PV) are synthetic vaccines (Nev- agi et al. 2018). They are synthesized in vitro using known immunogenic amino acids (~ 20 to 30 amino acids), which resemble antigenic sites and can trigger immune responses. PV are ...
& Toth, I. Peptide-based synthetic vaccines. Chem. Sci. 7, 842–854 (2016). Article CAS PubMed Google Scholar Li, W., Joshi, M. D., Singhania, S., Ramsey, K. H. & Murthy, A. K. Peptide vaccine: Progress and challenges. Vaccines (Basel) 2, 515–536 (2014). Article CAS ...
Toth Peptide-based synthetic vaccines Chem. Sci., 7 (2) (2016), pp. 842-854 View articleView in ScopusGoogle Scholar [4] P.M. Moyle, I. Toth Modern subunit vaccines: development, components, and research opportunities ChemMedChem, 8 (3) (2013), pp. 360-376 CrossrefView in Scopus...
Self-adjuvanting peptide-based vaccines commonly utilise the powerful TLR2 agonist PamnCys lipid to stimulate adjuvant activity. The chemical synthesis of lipidated peptides can be challenging hence efficient, flexible and straightforward synthetic routes to access homogeneous lipid-tagged peptides are in...
However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses. We show that Z2 ...
vaccines based on synthetic peptides encompassing B and T cell epitopes that precisely trigger a protective immune response. Because they are synthetic, peptide vaccines are intrinsically safer than alternative vaccine formulations. Moreover, peptide-based vaccines will allow focusing solely on relevant ...
There are two common strategies to engage TLR-2 through vaccines: conjugating the antigen to bacterial lipopeptides or to palmitic acid. Bacterial lipopeptide MALP-2 and its synthetic analogues like Pam2Cys and Pam3Cys are most frequently used. The peptide- lipopeptide construct were shown to ...
17,18 Conversely, anticancer vaccines under the category of active immunotherapy induce the engagement of the host immune system and the formation of immunological memory.19,20 Biological background Immune dysregulation and dysfunction result in cancer progression and therefore the aim of cancer ...
Both natural and synthetic polymers have been extensively explored and applied for vaccines delivery, mainly when used in the form of NPs. The polymer-based systems provide a lot of merits, including the ability to conjugate a range of antigens, flexibility in the design process, mimicking infect...