Thus, it is believed that the longevity of Ag presentation by peptide-pulsed DC is limited in vivo. Surprisingly, however, we found that although the majority of injected DCs disappeared from the draining lymph nodes within 7 days, Ag presentation persisted for at least 14 days followin...
Our previous work demonstrated peptide-pulsed mature myeloid dendritic cells (DC) presenting β cell antigens induce tolerance. Here we determine whether immature DC (iDC) presenting dominant (insulin β9–23 chain, proinsulin C19–A3) or ignored (glutamic acid decarboxylase 6578-97) antigen ...
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. Cancer Immunol Immunother 2007; 56: 1485-1499...
Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histocompatibility complex class I-presented peptide antigen pulsed onto dendritic APCs induces protective immunity to lethal challenge by a tumor transfected with the ...
Based on basic research results, a phase I clinical trial of HLA-A2 or A24-restricted melanoma peptide cocktail-pulsed dendritic cell-based immunotherapy has been performed. Here we describe the safety and efficacy of DC-based immunotherapy against metastatic melanoma....
Antigen-specific T cells were found in 2 of 15 patients vaccinated with wild-type gp100-loaded DC, versus 1 of 12 patients vaccinated with modified peptide-loaded DC. These three patients also had the best clinical response, with long-term (>8years) complete responses in two patients, one ...
Induction of CMV-specific T-cell lines using Ag-presenting cells pulsed with CMV protein or peptide. Cytotherapy 2002;4:49-54.Einsele H, Rauser G, Grigoleit U, et al. Induction of CMV-specific T-cell lines using Ag-presenting cells pulsed with CMV protein or peptide. Cytotherapy 2002;4(...
实验方案 技术支持 货号12-5743-82 CNY3,918.00 有货 查看价格 批量或定制请求 Application Created with Sketch. 图:1/16 OVA257-264 (SIINFEKL) peptide bound to H-2Kb Antibody (12-5743-82) in Flow Staining of BALB/c (left) or C57BL/6 splenocytes ...
reported the results of another trial, using a MART-1-specific TCR that targeted the HLA A2-restricted EAAGIGILTV peptide, in 14 melanoma patients, with the addition of dendritic cells (DC) vaccine pulsed with the same peptide. They found that 9 of the 13 treated patients (69%) showed ...
DC that were pulsed in vitro with the OVA peptide before injection. Interactions were also observed between paracortical DC of the recipient and OVA peptide-specific T cells after administration of intact OVA. Injection of OVA peptide-pulsed DC caused the specific T cells to produce IL-2 in ...