The impact of PEEP on ventilator-induced lung injury depends on the extent of dynamic strain reduction. We hypothesized that R/I may reflect the potential for lung recruitment (i.e. recruitability) and, consequently, estimate the impact of PEEP on dynamic lung strain, both assessed through ...
(1) a PEEP level of 12 cm H2O with alveolar recruitment maneuvers performed after endotracheal intubation, which were repeated every hour after any disconnection from the mechanical ventilator and before the end of surgery (high level of PEEP group) or (2) a PEEP level of 4 cm H2O (low ...
MATERIALS AND METHODS ~~~i~~~were conducted on 14 fetal goats with a mean gestational age of 131 days (0.87 of full term) and a range of 117-150 days. Nannies were anesthetized with chloralose, the fetus exteriorized, and a closed tracheal cannula secured before any ventilation. Catheter...
This randomized trial compares the effects of ventilator lung recruitment using PEEP titration vs a conventional low-PEEP strategy on 28-day mortality in
In this study, ventilator-driven alveolar lung recruitment will be performed using the incremental PEEP method with the target PEEP set at 20 cmH2O and the target Ppeak set at 40 cmH2O. Individualized PEEP will be obtained by Cstat titration in obese patients. The effect of iPEEP on perioper...
Data from our research on COVID-19-related ARDS identified rather a range of suitable PEEP levels where most parameters of lung mechanics during pressure-controlled ventilation show very similar values (Fig. 1). This range of PEEP levels was relatively wide: 5–8 cm H2O. Range of suitable ...
the clinical feasibility and acceptability of a P targeted mechanical ventilation strategy, to identify specific goals and safety limits when targeting a low P, and to determine whether patient outcomes can be improved by targ...
On each level of PEEP, ABGs will be collected and evaluated. Optimal PEEP is considered as the PEEP value resulting the highest possible Cstat measured by the ventilator. After the PEEP titration procedure, lung-protective mechanical ventilation will be performed using optimal PEEP and low tidal ...
PEEP and the Open Lung Approach Althoughmechanical ventilationis a life-saving intervention, it placessignificant stress and strain on the lung parenchyma. Damage at the pulmonary parenchymal and muscular levels from mechanical ventilation is termedventilator-induced lung injury(VILI). Major injuries, suc...
Positive pressure ventilation with the open lung concept opti- mizes gas exchange and reduces ventilator-induced lung injury in newborn piglets. Pediatr Res 2003;53:245–53. 24. Rimensberger PC, Cox PN, Frndova H, Bryan AC. The open lung during small tidal volume ventilation: concepts of ...