Vancomycin, Peak and Trough - Vancomycin is an antibiotic used in the treatment of bacterial infections, especially methicillin-resistant staphylococci. Vancomycin is also used in treatment for penicillin-allergic patients who cannot receive or have failed to respond to other drugs, including the pen...
Zokufa HZ, Rodvold KA, Blum RA, et al. Simulation of vancomycin peak and trough concentrations using five dosing methods in 37 patients. Pharmacotherapy 1989; 9(1): 10–6Zokufa HZ, Rodvold KA, Blum RA, Riff LJ, Fischer JH, Crossley KB, Rotschafer JC (1989) Simulation of vancomycin ...
The vancomycin peak and trough are two extremes of concentration of vancomycin in a person's bloodstream. It's important to know...
Vancomycin (VCM) is a glycopeptide antibiotic that was developed and used in the 1950s to treat aerobic Gram-positive infections, and is currently used...
Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date. We aimed to compare clinical and pharmacokinetic outcomes between peak-trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC 24...
The results suggest that as long as trough concentrations do not exceed 15 mg/L, peak levels will not exceed normally accepted safe concentrations, and therefore do not need to be measured.N.JSaundersSDOSLancetSaunders NJ. Why monitor peak vancomycin concentrations? Lancet. 1994;344:1748–50. ...
VANCOMYCINBLOOD collectionKIDNEY physiologyThe therapeutic drug monitoring (TDM) of vancomycin (VCM) in critically ill patients often results in the estimated area being under the concentration鈥搕ime curve (AUC) values that deviate from individual observations. In this study, ...
Because the association between vancomycin peak concentrations and toxicity is poor, some have recommended measuring trough concentration only4 as this study is clearly documenting, but others have suggested not measuring any concentrations in the majority of children with normal renal function.5 However,...
Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date. We aimed to compare clinical and pharmacokinetic outcomes between peak–trough-based and trough-only-based vancomycin TDM approaches and to determine the relationship between vancomycin AUC24...
Compared to trough-only-based TDM, peak-trough-based TDM was associated with less vancomycin total daily doses by 12.05mg/kg/day (p value=0.027). CART identified creatinine clearance (CL CR ), AUC 24 /MIC, and TDM approach as significant determinants of therapeutic outcomes. All patients [...