Vancomycin, Peak and Trough - Vancomycin is an antibiotic used in the treatment of bacterial infections, especially methicillin-resistant staphylococci. Vancomycin is also used in treatment for penicillin-allergic patients who cannot receive or have failed to respond to other drugs, including the pen...
The vancomycin peak and trough are two extremes of concentration of vancomycin in a person's bloodstream. It's important to know...
Among the 113 patients included in this study, 72 (64%) were in the 1-point group (trough only), whereas 41 (36%) were in the 2-point group (trough/peak). The percentage of patients achieving the target AUC at the follow-up TDM evaluation was significantly higher...
Prediction of gentamicin peak and trough concentrations from six extended-interval dosing protocols for neonates. Purpose. The ability of six extended-interval gentamicin dosing protocols to achieve desired peak and trough concentrations in neonates was evaluated using... Murphy,E John - American Journal...
Peak values 18-26 mg/L; trough values 5-10 mg/L; however, Infectious Diseases Society of America and other guidelines urge troughs 15-20 mg/L Only treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria to reduce development of drug-resistant bacteria ...
[6] Studies targeting vancomycin peak and trough concentrations of 30 and 10 mg/L, respectively, yet also reporting MICs of 2 mg/L and higher associated with failure to eradicate, do support the premise that higher AUC24/MIC values may correlate with improved outcomes, as we have also ...
pharmacokinetic variability of vancomycin arising from nonrenal factors, it seems impractical to rely exclusively on nomograms that are based on renal function alone. In addition, studies have shown that the published nomograms may significantly underpredict vancomycin steady-state peak and/or tr...
Simultaneous determination of cefepime, vancomycin and imipenem in human plasma of burn patients by high-performance liquid chromatography 文档格式: .pdf 文档大小: 174.12K 文档页数: 5页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度:
Clinical validation of the two-point method for predicting vancomycin AUC based on peak and trough plasma concentrationsArea under the curveChineseChinese older patientsMethicillin-resistantStaphylococcus aureusMinimum inhibitory concentrationPharmacokineticsTherapeutic drug monitoringVancomycin...
Peak-trough-based TDM was significantly associated with higher therapeutic cure rates compared to trough-only-based TDM [76.7% vs 48.6%; p value=0.02]. No statistically significant differences were observed for all-cause mortality, neutropenia, or nephrotoxicity between the two groups. Compared to ...