The initial mean dose of vancomycin was 47 mg/kg/day resulting in a mean peak and trough serum concentration of 19 and 6 渭g/mL, respectively. A mean of 2.2 (range, 1 to 5) and 2.1 (range, 1 to 5) peak and trough serum concentrations were reported for each patient, respectively. ...
— Trough: 0.5 mcg/mL Peak: 6.0 mcg/mL — Trough: 2.0 mcg/mL Peak: 9.9 mcg/mL Random: ≥ 2.0 mcg/mL Trough: ≥ 2.0 mcg/mL Peak: ≥ 10.0 mcg/mL Valproic acid 50 mcg/mL 99 mcg/mL ≥ 100 mcg/mL Vancomycin — Trough: 5 mcg/mL Peak: 20 mcg/mL — Trough: 10 mcg...
Results (mean+-SD): VCMmax, 83 +- 12 mug/ml (range 50-289); DELTAT, 12 +- 9 days; baseline SCr, 1.0 +- 0.3 mg/dl; peak SCr, 3.6 +- 2.1 mg/dl; albumin, 2.1 +- 0.6 g/dl; bilirubin, 3.8 +- 7.2 mg/dl. Oliguria was present in nine patients (47%) and seven (37%) ...
This guideline-recommended range is designed to ensure both the safety and efficacy of vancomycin, balancing optimal therapeutic outcomes with minimised risk of nephrotoxicity. 2. Results 2.1. Participants The demographic and clinical characteristics of the 12 healthy participants (three females, nine ...
The current reference range for trough concentrations is 12–46 mg/L [6], although some authors have proposed a more modest target range of 6–20 mg/L [7]. The favourable pharmacokinetic profile together with the absence of major drug interactions and broad therapeutic window makes routine ...