Cancer animal models over the years. The animal model of cancer was first introduced in 1918, but the beginning of today’s models was in 1951 with the development of the CDX models, but the development of other models led to competition for a more suitable model with more efficiency. The ...
表 1 不同部位移植成功率的比较 Table 1 Comparisons on the success rate of different transplantation sites 移植位点 Transplantation sites 肿瘤类型 Tumor types 移植成功率 Transplantation success rate 皮下移植 Subcutaneous transplantation 子宫内膜癌,非小细胞肺癌 Endometrial cancer, non⁃small cell lung ...
al. An integrative approach to precision cancer medicine using patient-derived xenografts [ J] . Mol Cells, 2016, 39(2) : 77-86. [ 5 ] Hidalgo M, Amant F, Biankin AV, et. al. Patient-derived xenograft models: an emerging platform for translational cancer research [ J] . Cancer ...
In cell line models of endocrine sensitive and resistant breast cancer both drugs impact the ER-cistrome, ER-interactome and transcription of oestrogen-regulated genes similarly, confirming the anti-oestrogenic activity of elacestrant. The addition of elacestrant to CDK4/6 inhibitors enhances the ...
23、势抗性前列腺癌(Castration Resistant Prostate Cancer,CRPC)患者生存期,缓解症状。这重新燃起了化学药物治疗前列腺癌的希望,研究者们陆续发起了多个多西他赛治疗前列腺癌的研究 。2006年,Yao T等61研究发现与单独多西他赛或去势治疗组的荷瘤小鼠相比,多西他赛治疗后去势组,表现出最有效的抗肿瘤作用。且经TUNEL测定证实...
this void, we analyzed 252 primary tumor samples from the SPORE/ICON project at MD Anderson Cancer Center that were used for generating PDXs and had comprehensive genomic, transcriptomic, and immune profiling data available to evaluate the parameters impacting the intake success of lung cancer PDXs....
Lurie Comprehensive Cancer Center. Parts of Figures 1–3 were generated using resources from BioRender.com. This work was supported by the Northwestern University NUSeq Core Facility. Research support was from the NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants R...
Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development during embryogenesis, whereas in the adult it controls 尾-cell function. Her... Ber,Idit,Shternhall,... - 《Journal of Biological Chemistry》 被引量: 333发表: 2003年 TargetingNUF2suppresses gastric cancer progression...
Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer We analyzed PDX-1 expression in human pancreatic cancer specimens, pancreatic cancer cell lines, and the effects of forced expression of PDX-1 in ... M Koizumi,R Doi,E Toyoda,... - 《Surgery》 被引量:...
Since cell density affects differentiation outcomes in standard unconfined monolayer cultures, we asked whether local cell density within the clusters correlates with these improved differentiaton profiles. As we have determined the overall trends for N:C ratios of PDX1 and NKX6.1, we studied the nuc...