涉及到的数据样品是 14 RMS PDX-derived primary cultures and 3 conventional aRMS cell lines ,简单的单细胞转录组数据分析,降维聚类分群,可以看到,如果不对这些样品进行整合,就是每个样品独立成群,这个是恶性肿瘤细胞的特性。当然了,如果强行走一下整合这个算法,也是可以抹平病人异质性的这样的话后续的分群就是功能...
Cell Death Disꎬ 2020ꎬ 11(2) : 92. [25] Chen Zꎬ Liu Zꎬ Zhang Mꎬ et al. EPHA2 blockade reverses acquired resistance to afatinib induced by EPHA2 - mediated MAPK pathway activation in gastric cancer cells and avatar mice [ J] . Int J Cancerꎬ 2019ꎬ 145(9) : 2440...
T-cell acute lymphoblastic leukemiaT-ALLKrasPdx1hematopoieticKC miceThe highly utilized KC model has a reported lethality rate of about 30%, which has been attributed to pancreas cancer. However, a competing cause of lethality in KC mice is due to the activation of mutant- Kras gene ( Kras ...
9. Vazquez Rodriguez G, Abrahamsson A, Jensen LD, Dabrosin C. Estradiol Promotes Breast Cancer Cell Migration via Recruitment and Activation of Neutrophils. Cancer Immunol Res. 2017;5:234–47. 10. Vazquez Rodriguez G, Abrahamsson A, Jensen LDE, Dabrosin C. Adipocytes Promote Early Steps of ...
9. Vazquez Rodriguez G, Abrahamsson A, Jensen LD, Dabrosin C. Estradiol Promotes Breast Cancer Cell Migration via Recruitment and Activation of Neutrophils. Cancer Immunol Res. 2017;5:234–47. 10. Vazquez Rodriguez G, Abrahamsson A, Jensen LDE, Dabrosin C. Adipocytes Promote Early Steps of...
表 1 不同部位移植成功率的比较 Table 1 Comparisons on the success rate of different transplantation sites 移植位点 Transplantation sites 肿瘤类型 Tumor types 移植成功率 Transplantation success rate 皮下移植 Subcutaneous transplantation 子宫内膜癌,非小细胞肺癌 Endometrial cancer, non⁃small cell lung ...
[15] de Miguel M, Calvo E. Clinical challenges of immune checkpoint inhibitors[J]. Cancer Cell, 2020, 38(3):326-333. doi: 10.1016/j.ccell.2020.07.004 [16] Zhao Y, Shuen TWH, Toh TB, et al. Development of ...
这一研究结果发表在Cancer Cell杂志上。 在这项新的研究中,EPFL科学家开发出了生物学上最忠实的雌激素受体阳性乳腺癌动物模型。他们的模型也已在临床前环境中,在人类乳腺组织中进行过测试。 在测试的新癌症药物中,大约百分之90的药物失败。部分的原因是,用来测试这些药物的动物模型,通常无法体现它们所代表的癌症的复...
[1] Mirhadi S, Tam S, Li Q, et al. Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes. Nat Commun. 2022 Apr 5;13(1):1811.doi: 10.1038/s41467-022-29444-9. ...
Haosheng Li, Haoran Feng, Tao Zhang, Junwei Wu, Xiaonan Shen, Shuiyu Xu, Lianghui Xu, Shaodong Wang, Yaqi Zhang, Wenqing Jia, Xiaopin Ji, Xi Cheng, Ren Zhao. CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib. Mol Cancer....