CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate an
Cell differentiation is the process by which specialised cells such as muscle, skin or nerve cells, are formed from less specialised cells such as stem cells and their progenitors. Differentiation occurs during development of an organism to produce new specialised cells, and also in adults to reple...
Wang ZM, Du WJ, Piazza GA, Xi Y: MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells. Acta Pharmacol Sin 2013, 34:1374-1380.Wang Z., Du W., Piazza G.A., Xi Y. (2013) MicroRNAs are involved in the self-renewal and differentiation of cancer stem ...
Research about intratumoural TCR repertoire demonstrated thatonly a small fraction of intratumoural CD8+ T cells (approximately 10% or less) had the capacity to recognize cancer cells. And there are cases, patients thereof, despite significant T cell infiltration into tumours, have no tumour react...
In the present study, we demonstrated that GSIs, such as MK-0752 and RO4929097, inhibit breast tumor growth, but increase the breast cancer stem cell (BCSC) population in Notch3-expressing breast cancer cells, in a process that is coupled with IL6 induction and is blocked by the IL6R ...
In this review, we will summarize the research progress in the study of miRNAs involved in the self-renewal and differentiation of cancer stem cells. 展开 关键词: 肿瘤干细胞;分化能力;自我更新;微RNA;癌症;miRNA;非编码RNA;基因表达 DOI: 10.1038/aps.2013.134 被引量: 11 ...
A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells Hema Preethi Subas Satish Sweta Iyer Ruth M. Kluck ArticleOpen Access06 Apr 2024 Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 actio...
Stem cells can be classified as pathology cervical cancer cells are divided into the following categories: low polarization, divide, and the high degree of differentiation, cell differentiation and cancer of the cervix is closely linked the prognosis. ...
Tissue culture medium routinely contains fetal bovine serum (FBS). Here we show that culturing human hepatoma cells in their native, adult serum (human serum, HS) results in the restoration of key morphological and metabolic features of normal liver cells. When moved to HS, these cells show di...
Temporal dissection of the roles of Atg4 and ESCRT in autophagosome formation in yeast Hui Li Jing-Zhen Song Zhiping Xie Article23 Dec 2024 Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state ...