Sahlen G et al, Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases. Prostate 61; 2004: 291-297.Sahlen G, Ahlander A, Frost A, Ronquist G, Norlen BJ and Nilsson BO: Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases. ...
T cells can also recognize cancerous cells and, once activated, have anti-tumor or cytotoxic abilities. All T cells begin as stem cells in the bone marrow. These undifferentiated cells migrate from the bone marrow into the thymus, where they acquire identifying surface markers, such as CD3, ...
How regular cells are similar to cancer cells?Cells:Cells are the smallest unit of life. Cells can be eukaryotic, meaning they possess true nuclei and membrane-enclosed organelles. They can also be prokaryotic, meaning they lack both of these features and only have a nucleus-like region called...
1b). This conditioned media was transferred to naive differentiated C2C12 myotubes (Fig. 1a). Conditioned media from palmitate-treated C2C12 myotubes increased expression of UPR genes Atf4, Hspa5 and Edem1 (Fig. 1b). To determine the relevance of this phenotype in a human model, primary human...
Dendritic cells differentiated in the presence of IFN-β and IL-3 are potent inducers of an antigen-specific CD8+ T cell responsecancerimmunotherapyDendritic cells (DC) are professional antigen-presenting cells that are used in vaccine approaches to cancer. Classically, mature monocyte-derived DC ...
Entrena5,6, Carmen Griñán-Lisón1,2, Margarita Aguilera2,7, Manuel Picon-Ruiz1,2,8 & Juan A. Marchal1,2,3 Cancer stem cells are responsible for tumor progression, metastasis, therapy resistance and cancer recurrence, doing their identification and isolation of special ...
Here, we compare mouse and human NKG2D-CAR-expressing T cells, natural killer (NK) cells, and macrophages against glioblastoma, the most aggressive primary brain tumor. In vitro we show that T cell cancer killing is CAR dependent, whereas intrinsic cytotoxicity overrules CAR dependence for NK ...
SW48 cells, and SW1116 cells. These results suggest that the lack of growth inhibition by TGF-beta in SW48 and SW1116 colon cancer cells may be caused by a lack of expression of functional TGF-beta receptors. 展开 关键词: Humans Epithelium Tumor Cells, Cultured Colonic Neoplasms DNA, ...
Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans1,2,3. To provide immunity, transiently stimulated CD8+ T cells undergo unusually rapid bursts of numerous cell divisions, and then form quiescent long-lived memory cel...
8b). Regarding more differentiated progenitor cells, Lin−c-KitlowSca-1lowCD127+CD135+ (common lymphoid progenitors (CLPs)), Lin−c-Kit+Sca-1−CD34+CD16/32− (CD34+ common myeloid progenitors (CMPs)) and Lin−c-Kit+Sca-1−CD34−CD16/32− (bipotent megakaryocyte/erythrocyte...