but it is possible that other mechanisms may eventually emerge".I agree with Henry Harris that cancer originates as a disease of differentiation and I propose such an emerging mechanism in the December issue of Bioessays.In my opinion, the stem-cell-like properties of cancer cells rather result...
(細胞平衡) Proliferation Differentiation Death Transit Renewing Proliferating Exiting Cancer: disruption of cellular equilibrium Proliferation Differentiation Death Stem cells as the target of carcinogens Stem cell Post mitotic Differentiated Normal senescent differentiated cell Benign tumor Grade 2 malignancy ...
Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2:365-372.Sommers, C. L., Thompson, E. ......
Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that co...
The mutational impact of culturing human pluripotent and adult stem cells Article Open access 19 May 2020 References Sell, S. & Pierce, G. B. Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers. Lab. Invest. ...
Among the hit compounds, we identified oxadiazole- and oxazole-based chemical probes as potential cell lineage- and cell differentiation-specific inhibitors of NF-κB ("NLDSi" = NF-κB lineage, differentiation-specific inhibitors). Using a panel of cell lines with stably integrated NF-κB-driven ...
Stem Cell Biology Pathways TGF Beta Signaling Pathway THC Differentiation Pathway TNF Signaling Pathway TNF Superfamily Pathway Transcription Factors Pathways Transendothelial Migration of Leukocytes Tumoricidal Effects of Hepatic NK Cells TWEAK Pathway ...
Cancer stem cells (CSCs) biology has come of age. The CSC theory is currently central to the field of cancer research, because it is not only a matter of academic interest but also crucial for the cancer therapy and prevention. Most cancers comprise of a
[69]. Given the well-known periostin functions in cancer, the question remains as to which mechanism is at work. In fact, periostin induces tumor growth via promoting cell proliferation or escaping apoptosis. To elucidate the role of periostin in the progression of cancer cell proliferation, ...
tRNA flux and consistency in differentiation EPAC1 enhances brown fat growth and beige adipogenesis EPAC1 boosts thermogenic adipocyte formation Cell origin of BRCA2-mutant breast cancer Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutat...