PDPN-Mock cells. Consistently, the CAF/PDPN-OE group had significantly increased tumor volume and weight compared with the CAF/PDPN-Mock group (Fig.2F). Moreover, immunohistochemistry staining confirmed that PDPN-overexpressing CAFs caused increased Ki67 expression in SCC15 cells (Fig.2G), which i...
Results: Seventy-two patients (44%) showed PDPN expressing in CAFs(CAF+), while fifty-seven patients (35%) showed the infiltration of platelets in tumor tissue (CD61+). Correlation analysis showed a significant correlation between multiple sets of data, including CAF+ with clinical stage (P=0...
However, due to the high heterogeneity of CAFs, elucidating the molecular mechanism of CAF-mediated tumor angiogenesis remained elusive. In our study, we found that there is pro-angiogenic functional heterogeneity of CAFs in colorectal cancer and we clarified that Podoplanin (PDPN) can specifically ...
结果:PDPN在大多数癌組织中表达量增加,起到促癌基因的作用,部分癌组织中,PDPN表达量下降,仍可导致恶性肿瘤透展;PDPN表达量的高低与某些恶性肿瘤预后具有显著相关性;PDPN与多种免疫细胞尤其是肿瘤相关成纤维细胞(CAF)之间表现出显著的相关性,提示PDPN与肿瘤免疫浸润相关,可能参与肿瘤微环境的调控。PDPN参与调控多种...
Two main CAF subpopulations are also found in human breast tumors, where their ratio is associated with disease outcome across subtypes and is particularly correlated withmutations in triple-negative breast cancer. These findings indicate that the repertoire of CAF changes over time in breast cancer ...