非小细胞肺癌对于PDL1-T细胞的治疗是有效的。但有些高突变的肿瘤中却缺乏CD8 T细胞的浸润,降低了CAR-T的疗效,因为进不去。 研究发现,肿瘤的突变有助于CD8 T细胞的浸润,但超过一定数量的突变,会导致肿瘤内部激活Wnt-betaCatenin信号通路,从而排斥CD8 T细胞的浸润。 因此本文借助研究出的这个机制,提出PDL1-T和Wnt-...
The present invention provides methods and compositions for converting a T cell into a cell that exhibits at least one regulatory T cell phenotype. The converted T cell is generated by contacting a T cell with a cell that is modified to comprise an agent capable of activating PD1 signaling in...
natural killer T cellPD1/PDL1-Galactosylceramide (-GalCer)-activated natural killer T (NKT) cells have antiviral properties against hepatitis B virus (HBV). However, -GalCer activation of NKT cells can induce anergy. We hypothesized that this effect may be overcome by a treatment strategy that ...
以下八个组包含彼此保守取代的氨基酸:1)丙氨酸(a),甘氨酸(g);2)天冬氨酸(d),谷氨酸(e);3)天冬酰胺(n),谷氨酰胺(q);4)精氨酸(r),赖氨酸(k);5)异亮氨酸(i),亮氨酸(l),蛋氨酸(m),缬氨酸(v);6)苯丙氨酸(f),酪氨酸(y),色氨酸(w);7)丝氨酸(s),苏氨酸(t);和8)半胱氨酸(c),蛋氨酸(m)(...
双特异性治疗比αCD47,αPD-L1单一疗法或其在同源肿瘤模型中的组合产生了更有利的治疗窗口。且促进效应CD8 T cells的转变增加。 在NHP和小鼠系统中给予αCD47 / PD-L1双特异性抗体显示贫血轻微,但保持较强的先天性和适应性免疫应答。确定了独特的骨髓和T细胞活化模式,证明了其参与先天性和适应性免疫反应以增强抗...
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Ni X,Song Q,Cassady K,et al. PD-L1 interacts with CD80 to regulate graftversus-leukemia activity of donor CD8 + T cells[J]. J Clin Invest,2017,127( 5) : 1960. TAO LL,LAI X,WEI J.PD -1 /PD -L signaling pathway in chronic hepatitis B[J].J Clin Hepatol,2016,32( 12) : 237...
PDL1 can be expressed on the surface of tumour cells, immune cells and other cells in the tumour microenvironment but is also found in extracellular forms. Recent studies have explored the importance of different forms of extracellular PDL1, such as on exosomes or as a freely soluble protein,...
PD-1/PD-L1途径在脓毒症T淋巴细胞和单核细胞中的作用及机制研究 摘要 脓毒症(sepsis)是一种创伤、感染等引起机体过激的炎症反应从而对人体产生 严重危害的疾病,死亡率极高。近年来,随着科学家对脓毒症的深入研究,发现其病 程变化中免疫系统的功能障碍是脓毒症中的一个突出问题。脓毒症过程中,机体非特 异免疫...