The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and PatterningLangerhans cells (LC), the dendritic cells of thedoi:10.4049/JIMMUNOL.1501520Rossana ZaruStephen P. MatthewsAlexander J. EdgarAlan R. PrescottDiego Gomez-Nicola
p90 RSK is the kinase of pro-Casp8. It is activated by a mechanism that does not need ERK but PDK1, which is recruited to the RIP1-RIP3-MLKL-containing necrosome. Phosphorylation of pro-Casp8 at Thr265 can substitute for zVAD to permit necroptosis in vitro. pC8T265 mimic T265E ...
Interestingly, the RSK family members, Mitogen and Stress-activated Kinase-1 and -2 (MSK1/2), can be activated independent of PDK1 but remain sensitive to TPCK. This implies that TPCK disrupts not only PDK1-dependent signaling, but also signaling of PDK1-related kinases. Defining the molecular...
Activation of PDK1/RSK Results in Aquaporin-2 S256 Phosphorylation and Membrane Accumulation After Downregulation of EGFR Signalingdoi:10.1681/ASN.20223311S1141aRichard S. BabiczPui Susan W. CheungRichard BouleyNoah BaylorDennis BrownAmerican Society of Nephrology...