p90 RSK is the kinase of pro-Casp8. It is activated by a mechanism that does not need ERK but PDK1, which is recruited to the RIP1-RIP3-MLKL-containing necrosome. Phosphorylation of pro-Casp8 at Thr265 can substitute for zVAD to permit necroptosis in vitro. pC8T265 mimic T265E ...
The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and PatterningLangerhans cells (LC), the dendritic cells of thedoi:10.4049/JIMMUNOL.1501520Rossana ZaruStephen P. MatthewsAlexander J. EdgarAlan R. PrescottDiego Gomez-Nicola
Our data show that RSK and PDK1 are terminal effectors in the novel, PKA-independent pathway of AQP2 activation induced by erlotinib. Further elaboration of this new non-canonical pathway promises to uncover potential pharmacological targets for the treatment of water balance disorders.This work was...
Interestingly, the RSK family members, Mitogen and Stress-activated Kinase-1 and -2 (MSK1/2), can be activated independent of PDK1 but remain sensitive to TPCK. This implies that TPCK disrupts not only PDK1-dependent signaling, but also signaling of PDK1-related kinases. Defining the molecular...
Activation of PDK1/RSK Results in Aquaporin-2 S256 Phosphorylation and Membrane Accumulation After Downregulation of EGFR Signalingdoi:10.1681/ASN.20223311S1141aRichard S. BabiczPui Susan W. CheungRichard BouleyNoah BaylorDennis BrownAmerican Society of Nephrology...