p90 RSKphosphorylationzVADNecroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. It has been unclear how the Casp8 blockade of necroptosis is eliminated naturally. Here, we show that pro-Casp8 within the ...
PDK1, pAKT (S473), pAKT (T308), pS6K (T389), pS6 (S240/4), pS6 (235/6), p4EBP1 (S65), PARP, Actin, pRSK (S227), cleaved caspase 3, pFOXO1/3 (T24/T32), SGK1, SGK2, SGK3, pNDRG1 (T346), NDRG1, FLAG, HA, and phospho-RXRXX(S/T) were from Cell Signaling ...