The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and PatterningLangerhans cells (LC), the dendritic cells of thedoi:10.4049/JIMMUNOL.1501520Rossana ZaruStephen P. MatthewsAlexander J. EdgarAlan R. PrescottDiego Gomez-Nicola
同时,多种其他翻译后修饰也被证明直接决定AKT激酶活性。此外,除AKT外,许多其他AGC家族成员,包括S6K、血清和糖皮质激素诱导蛋白激酶(SGK)、polo样激酶1(PLK)、核糖体S6激酶(RSK)和蛋白激酶C(PKC),也参与PDK1介导的磷酸化和活化,促进PDK1的多种生物...
clone id:ep569y swiss prot:o15530 mol weight:64kda size:100ul price: view datasheet description 3-phosphoinositide-dependent protein kinase-1 (pdk1) is a serine/threonine protein kinase known to phosphorylate and activate pkb/akt (thr308 and ser473), p70 s6 kinase, rsk, pka, pkc and sgk...
One of these enzymes was MAP kinase-activated protein kinase-1 (MAPKAP-K1, also known as p90rsk), a component of the classical MAP kinase cascade, while the other was p70 S6 kinase, the enzyme which mediates the phosphorylation of ribosomal protein S6 [36]. S6 phosphorylation is induced by...
Vascularendothelialcells;Cellconnection;Knockout3-磷酸肌醇依赖性蛋白激酶-1(3-phosphoinositide-dependentproteinkinase-1,PDK1)是蛋白激酶B(PKB/Akt)、p70核小体S6激酶(p70ribosomalS6kinase,S6K)、p90核小体S6激酶(p90ribosomalS6kinase,RSK)、血清和糖皮质激素诱导激酶(SGK)以及蛋白激酶C(PKC)等AGC激酶活化环的...
(residues 51–359); p38α, 38-kDa protein kinase-α; PH, pleckstrin homology domain; PIF, PDK1-interacting fragment; PKA, cAMP-dependent protein kinase; PKB, protein kinase B; PKC, Ca2+-activated protein kinase; ROCKII, human Rho-kinase; RSK, 90-kDa 40 S ribosomal protein S6 kinase; ...
(SGK), protein kinase C (PKC) and polo-like kinase 1 (PLK1)5. Specifically, the phosphorylation event occurred in the hydrophobic motif is primarily identified for PDK1 interaction with and phosphorylation of most of the AGC kinases, including S6K, RSK and SGK4. By contrast, PDK1-mediated ...
pdk1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating rsk2.[2016][cell immunol][10.基因促进炎性纤维母通过磷酸化的rsk2 synoviocyt.pdf 2017-03-26上传 pdk1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating rsk2.[2016][cell immunol...
展开 被引量: 3 摘要: 本发明涉及新的式(I)化合物和它们的药用组合物和它们的使用方法.这些新的化合物具有CHK1激酶抑制活性,PDK1抑制活性和Pak激酶抑制活性,因此用于癌症的治疗和/或预防. 展开 收藏 引用 批量引用 报错 分享 文库来源 其他来源 免费下载 求助全文 取代的杂环及其作为CHK1、PDK1和PAK抑制剂...
RPS6KA2RPS6KA2RPS6KA2HU-2, RSK3 PDPK1/PDK1 Protein PDPK1/PDK1 protein function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p7...