p90 RSKphosphorylationzVADNecroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. It has been unclear how the Casp8 blockade of necroptosis is eliminated naturally. Here, we show that pro-Casp8 within the ...
同时,多种其他翻译后修饰也被证明直接决定AKT激酶活性。此外,除AKT外,许多其他AGC家族成员,包括S6K、血清和糖皮质激素诱导蛋白激酶(SGK)、polo样激酶1(PLK)、核糖体S6激酶(RSK)和蛋白激酶C(PKC),也参与PDK1介导的磷酸化和活化,促进PDK1的多种生物...
Phosphoinositide-dependent protein kinase 1 (PDK1) plays a central role in many signal transduction pathways (1,2) including the activation of Akt and the PKC isoenzymes p70 S6 kinase and RSK (3). Through its effects on these kinases, PDK1 is involved in the regulation of a wide variety of...
(residues 51–359); p38α, 38-kDa protein kinase-α; PH, pleckstrin homology domain; PIF, PDK1-interacting fragment; PKA, cAMP-dependent protein kinase; PKB, protein kinase B; PKC, Ca2+-activated protein kinase; ROCKII, human Rho-kinase; RSK, 90-kDa 40 S ribosomal protein S6 kinase; ...
PDK1 可以通过激活 Akt、S6K、RSK、SGK 和 PKC 等激 酶来调节胰岛素和生长因子的生理效应,控制细胞生长、分化、生存、蛋白质 翻译和葡萄糖代谢。这使 PDK1 成为众多促生长信号通路中的中心激活者,在 细胞代谢、生长、增殖和存活等生理过程中具有重要作用。PDK1 在细胞中分 布广泛,并可通过调节至少 23 种激动剂...
生化机理 GSK2334470 是一种高度特异性的 PDK1(3-磷酸肌醇依赖性蛋白激酶-1)强效抑制剂。GSK2334470 可用于细胞中消减 T 环磷酸化,激活 SGK、S6K1 和 RSK,并抑制 Akt 的激活。新颖、强效的 PDK1(3-磷酸肌醇依赖性蛋白激酶 1)抑制剂(IC 50 = ~10 nM),对其他密切相关的 AGC 激酶没有活性。 储存温度 -...
RPS6KA2RPS6KA2RPS6KA2HU-2, RSK3 PDPK1/PDK1 Protein PDPK1/PDK1 protein function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p7...
Miscellaneous/General:PDK1, a serine/ threonine kinase, functions as a master kinase, phosphorylating and activating Akt, S6K and RSK and is expressed ubiquitously. PDK1 has been shown to be essential for mouse embryonic development and regulates cell size independently of cell number or proliferation...
关键词: Colon cancer Rectal cancer S6K RSK PDK1 Akt CIMP KRAS2 DOI: 10.1016/j.mrfmmm.2010.10.005 被引量: 64 年份: 2011 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 Elsevier Elsevier (全网免费下载) 掌桥科研 万方医学 dx.doi.org 查看更多 相似文献 参考文献 ...
Furthermore, whereas both PDK1 and the Mitogen-ActivatedProtein Kinase (MAPK) are required for full activation of the ninety kilodaltonRibosomal S6 kinase (RSK), TPCK inhibited RSK activation without inhibiting MAPK activation. Consistent with the capacity of RSK and Akt to mediate a cell survival ...