Platelet-derived growth factor receptor alpha (PDGFR alpha) is a dominant marker of mesodermal mesenchymal cells in mice. Previous studies demonstrated that PDGFR alpha-positive (PDGFR alpha+) mesodermal cells develop not only into mesenchymal cells but also into a subset of total hematopoietic cells...
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodim...
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodim...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook PDGFRA (redirected fromPDGFR-alpha) PDGFRA A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating ...
These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies ...
cells and is a therapeutic target of imatinib.The PDGFRA gene contains 23 exons spanning about 65kb.Using the human PDGFRA promoter linked to a luciferase reporter,Joosten et al.showed that PAX1 acts as a transcriptional activator of the PDGFRA gene in differentiated human embryonal carcinoma cells...
Cells were not fixed. This data was developed using the same antibody clone with 98141-1-PBS in a different storage buffer formulation.View All Images (6) Sandwich ELISA standard curve of MP01256-4 Sandwich ELISA standard curve of MP01256-4, Human PDGFR alpha/CD140a Recombinant Matched ...
This ultimately leads to growth and proliferation in cells by the MAPK and STAT transcription factor activation. PDGFRA is negatively regulated by protein phosphatases to cause inactivation and internalization. Due to PDGFRA's role in cellular growth its dysfunction may lead tumourigenesis. A high ...
The Pattern of Enhancement of Src Kinase Activity on Platelet-derived Growth Factor Stimulation of Glioblastoma Cells Is Affected by the Integrin Engaged Enhanced expression of both integrin alpha v beta 3 and platelet-derived growth factor receptor (PDGFr) has been described in glioblastoma tumors. ...
by PIK3R1. This ultimately leads to growth and proliferation in cells by the MAPK and STAT transcription factor activation. PDGFRA is negatively regulated by protein phosphatases to cause inactivation and internalization. Due to PDGFRA's role in cellular growth its dysfunction may lead tumourigenesis....