The PDGF B-chain homodimer PDGF BB activates both α- and β-receptor subunits (α-PDGFR and β-PDGFR), and promotes cell migration in many cell types including fibroblasts and smooth muscle cells. PDGF-A chain homodimer PDGF AA activates α-PDGFR only, and its role for cell migration is ...
In addition, both TGF-beta and Cbl regulated platelet-derived growth factor receptor-alpha (PDGFRalpha) expression in vivo and in isolated mammary fibroblasts. The hypothesis that TGF-beta mediates the levels of PDGFRalpha protein via regulation of c-Cbl was tested. We conclude that TGF-beta ...
Under stringent conditions, a single 6.4-kb RNA transcript was detected in poly(A)+ RNA prepared from normal human fibroblasts (data not shown). This transcript differed in size from previously reported transcripts for the PDGF-R (6), c-fms (3) or c-kit genes (7). All of these ...
Conditional expression of the constitutively active PDGFRD842V mutation in Collagen-I+ fibroblasts, during injury/repair, hindered the repair phase and instead promoted fibrosis. In DMD, treatment of mdx mice with crenolanib, a highly selective PDGFR/ tyrosine kinase inhibitor, reduced fibrosis, ...
Effect of siRNA-mediated depletion of PDGFR-alpha on infection efficiency in fibroblasts and endothelial cells.Cora, StegmannDaniel, HochdorferDiana, LieberNarmadha, SubramanianDagmar, StöhrKerstin, Laib SampaioChristian, Sinzger
Concomitantly, S1Plow mice have increased content of BMSC with higher ROS levels and glucose uptake, leading to higher BM content of colony-forming unit fibroblasts. Our results reveal a dynamic and inverse metabolic relationship between BM HSC and the stroma microenvironment. We hypothesized that ...
FibroblastsLungReceptorPlatelet-Derived Growth Factor alphaStaurosporine成纤维细胞肺星状孢子素Upregulation of the platelet-derived growth factor (PDGF) receptor-alpha (PDGFR-alpha) is a mechanism of myofibroblast hyperplasia during pulmonary fibrosis. We previously identified interleukin (IL)-1beta as a ...
PDGFRa inhibited the formation of adipocytes from these precursors while favoring the formation of stromal fibroblasts. This imbalance between adipocytes and stromal cells was accompanied by overexpression of the cell fate regulator Zfp521. PDGFRa activation also inhibited the formation of juvenile beige ...
PDGF3D cell culturePURPOSE. The goal of this study was to examine the mechanism behind the unique differential action of transforming growth factor beta 3 (TGF-beta 3) and TGF-beta 1 on SMA expression. It was our hypothesis that platelet-derived growth factor receptor a (PDGFRa) played a ...
We also found that TGF-beta signaling reduces PDGFR alpha expression in FAPs, mouse dermal fibroblasts and in two related mesenchymal cell lines. Moreover, TGF-beta promotes myofibroblast differentiation of FAPs but inhibits their adipogenicity. Accordingly, TGF-beta impairs the expression of PDGFR ...