Platelet-derived growth factor receptor alpha (PDGFR alpha) is a dominant marker of mesodermal mesenchymal cells in mice. Previous studies demonstrated that PDGFR alpha-positive (PDGFR alpha+) mesodermal cells develop not only into mesenchymal cells but also into a subset of total hematopoietic cells...
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodim...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook PDGFRA (redirected fromPDGFR-alpha) PDGFRA A gene on chromosome 4q12 that encodes a tyrosine-protein kinase which acts as a cell surface receptor for PDGFA, PDGFB and PDGFC, playing a key role in regulating ...
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodim...
1x10^6 MG-63 cells (left) or A-172 cells (right) were surface stained with 0.25 ug Anti-Human PDGFR alpha/CD140a Rabbit Recombinant Antibody (98141-1-RR, Clone: 241658H4) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This ...
cells and is a therapeutic target of imatinib.The PDGFRA gene contains 23 exons spanning about 65kb.Using the human PDGFRA promoter linked to a luciferase reporter,Joosten et al.showed that PAX1 acts as a transcriptional activator of the PDGFRA gene in differentiated human embryonal carcinoma cells...
This ultimately leads to growth and proliferation in cells by the MAPK and STAT transcription factor activation. PDGFRA is negatively regulated by protein phosphatases to cause inactivation and internalization. Due to PDGFRA's role in cellular growth its dysfunction may lead tumourigenesis. A high ...
Background:This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is...
Positive WB detected in THP-1 cells, HT-1080 cells, HUVEC cells, U-251 cells 推荐稀释比 ApplicationDilution Western Blot (WB) WB : 1:2000-1:20000 It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in valida...
The Pattern of Enhancement of Src Kinase Activity on Platelet-derived Growth Factor Stimulation of Glioblastoma Cells Is Affected by the Integrin Engaged Enhanced expression of both integrin alpha v beta 3 and platelet-derived growth factor receptor (PDGFr) has been described in glioblastoma tumors. ...