Crosstalk between pericytes and endothelial cells is critical for ocular neovascularization. Endothelial cells secrete platelet-derived growth factor (PDGF)-BB and recruit PDGF receptor β (PDGFRβ)–overexpressing pericytes, which in turn cover and stabilize neovessels, independent of vascular endothelial ...
The receptor tyrosine kinase PDGFR beta is essential for pericyte migration to the endothelium. In mice lacking one allele of PDGFR beta (PDGFR beta(+/-)), previous reports have described an age-dependent loss of pericytes in the brain, leading to cerebrovascular dysfunction and subsequent ...
Although the mechanism for this is not currently understood, we propose that inflammation modulates pericytes specifically and therefore alters the condition of the BBB/BSCB. One potential mechanism might be the regulation of signalling through the platelet-derived growth factor receptor-beta (PDGFRβ)....
免疫原 PDGFR beta/CD140b fusion protein Ag4285 种属同源性预测 宿主/亚型 Rabbit / IgG 抗体类别 Polyclonal 产品类型 Antibody 全称 platelet-derived growth factor receptor, beta polypeptide 别名 PDGFRB, JTK12, EC:2.7.10.1, CD140B, CD140 antigen-like family member B 计算分子量 1106 aa, 124 kD...
One potential mechanism might be the regulation of signalling through the platelet-derived growth factor receptor-beta (PDGFRβ). This is a well-known receptor tyrosine kinase, commonly used as a marker for pericytes, and is crucial to the regulation of survival, proliferation, and migration signal...
subchondral bone might also be derived from other nonendothelial sources, such as pericytes;29however, endothelial PDGFR-β in CD31hiEmcnhiECs was the primary modulator of H-type vessel formation. Triple immunostaining of CD31, endomucin, and leptin receptor (LepR) or Nestin demonstrated that the ...
We exposed primary adult human brain pericytes to chronic interferon-gamma (IFNγ) for 4days and measured associated functional aspects of pericyte biology. Specifically, we examined the influence of inflammation on platelet-derived growth factor receptor-beta (PDGFRβ) expression and signalling, as ...
[18]Dohgu S,Takata F,Yamauchi A,et al.Brain pericytes contribute to the induction and up-regulation of bloodbrain barrier functions through transforming growth factor-beta production[J].Brain Res,2005,1038:208-215.DOI:10.1016/j.brainres.2005.01.027. [19]Smyth LCD,Highet B,Jansson D,et al...
(M2-like) macrophages mediates cross talk between macrophages and pericytes in GBM via paracrine PDGFB-PDGFR尾 signaling, promoting pericyte recruitment and ... C,Zhu,I,... - 《Oncogene》 被引量: 8发表: 2017年 Immunolocalisation of PDGFRβ and pericytes in CADASIL Aims Cerebral autosomal domin...
Results PDGF signalling induces chemokine production from VSMCs We previously showed that a Cre-inducible gain-of-function knockin mutation in PDGFRβ (PDGFRβD849V) induced chemokine mRNA expression in brain pericytes and caused inflammation of the central nervous system18. To characterize chemokine ...