Upon inhibition of the PI3K pathway, PDGF D/beta-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF D/beta-PDGFR ...
Ultimately, the activation of PDGFRβ signaling pathway induces various cellular responses, including cell proliferation and migration.Angiogenesis is believed to be essential for both tumor growth and metastasis. Development of a vascular system, or vasculogenesis, involves the assembly of two principal ...
signaling pathway wound healing response to hydrogen peroxide negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of m...
It is thus likely that cell swelling via activation of ERK1/2 and cell shrinkage via activation of the p38 and JNK pathway and inhibition of the PDGFR signaling pathway may act as key players in the regulation of tissue homeostasis.Nielsen MB...
These results provide functional evidence that elevated PDGFR beta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.He, ChaoyongMedley, Shayna C.Kim, JangSun, ChengyiKwon, Hae Ryong...
The purpose of this study was to investigate the role of the PDGFR-beta/IRF9/SIRT-1/NF-kappa B pathway in VSMC phenotypic transformation after subarachnoid hemorrhage (SAH). SAH was induced using the endovascular perforation model in Sprague-Dawley rats. PDGFR-beta small interfering RNA (siRNA...
H2S, along with CO and NO, has been recognized as the third physiological gas signaling molecule that plays an active role in fighting various lung infections. However, the mechanism by which GYY4137 affects cecal ligation and puncture (CLP)-induced acute lung injury (ALI) is not understood. ...
Signaling through PDGFRβ regulates pericyte survival, proliferation, and migration. In TLE, we observed increased PDGFRβ expression in hippocampal blood vessels as expected, but also in nervous tissue parenchymal cells, suggestive of rearrangement in PDGFRβ distribution. The morphology and the ...