PDGF signaling inhibits mitophagy in glioblastoma stem cells through N6-methyladenosine. Authors - Deguan Lv KD Validated View Article human Cell Rep Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells Authors ...
with dual targeting of the tyrosine kinase activity of Tel/PDGFRβ and the MEK/ERK pathway completely preventing Tel/PDGFRβ-induced differentiation.ConclusionThese findings suggest that targeted disruption of key signaling pathways in combination with the tyrosine kinase activity of leukemic oncogenes, ...
Ultimately, the activation of PDGFRβ signaling pathway induces various cellular responses, including cell proliferation and migration.Angiogenesis is believed to be essential for both tumor growth and metastasis. Development of a vascular system, or vasculogenesis, involves the assembly of two principal ...
The purpose of this study was to investigate the role of the PDGFR-beta/IRF9/SIRT-1/NF-kappa B pathway in VSMC phenotypic transformation after subarachnoid hemorrhage (SAH). SAH was induced using the endovascular perforation model in Sprague-Dawley rats. PDGFR-beta small interfering RNA (siRNA...
Upon inhibition of the PI3K pathway, PDGF D/ ?-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF D/?-PDGFR signaling...
These results provide functional evidence that elevated PDGFR beta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.He, ChaoyongMedley, Shayna C.Kim, JangSun, ChengyiKwon, Hae Ryong...
It is thus likely that cell swelling via activation of ERK1/2 and cell shrinkage via activation of the p38 and JNK pathway and inhibition of the PDGFR signaling pathway may act as key players in the regulation of tissue homeostasis.Nielsen MB...
Upon inhibition of the PI3K pathway, PDGF D/beta-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF D/beta-PDGFR ...
H2S, along with CO and NO, has been recognized as the third physiological gas signaling molecule that plays an active role in fighting various lung infections. However, the mechanism by which GYY4137 affects cecal ligation and puncture (CLP)-induced acute lung injury (ALI) is not understood. ...