Background:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and ...
目前,PD-1 /PD-L1信号通路的许多环节尚不明确,随着对 PD-1 与肝脏疾病关系的研究逐渐深入,有助于从细胞及分子水平进一步了解肝脏疾病的发生及发展机制,为探索肝脏疾病的免疫治疗提供新的策略。 Ishida Y,Agata Y,Shibahara K,et al.Induced expression of PD-1,a novel member of the immunoglobulin genesuperfa...
These mice carry loxP sites flanking target exons of Gdpd1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gdpd1 gene. *使用本品系发表的文献需注明: Gdpd1-Flox mice (Cat. NO. TBD) were purchased from...
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large number...
Background This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and ...
The immune response in neonatal hearts from PD1 knockout mice was characterized by increased monocyte infiltration, a pro-inflammatory gene signature and exacerbated T cell activation. Our findings reveal a previously unrecognized role of the PD1/PD-L1 pathway in heart regeneration through modulation ...
Li CWet al.Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. 种属反应 :Mouse 显示更多 + 我要回报文献 产品评论 目前没有使用PD1 antibody [NAT105] (GTX20256)的产品评论被收录。快发表第一篇产品评论吧!
Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expressionstrainexpressioneffectmuscleremovalAmpd1tm1c/tm1canalysiscassettemiceinfluenceAMPD1 is an adenosine monophosphate deaminase that catalyzes the deamination of AMP to IMP. To understand ...
Using both overexpression of PDL1 and blocking antibodies against PDL1, the authors show that perturbing the PD1 pathway can influence tumour growth in mice. CAS PubMed PubMed Central Google Scholar Iwai, Y., Terawaki, S. & Honjo, T. PD-1 blockade inhibits hematogenous spread of poorly ...
Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mice with Lewis Lung Carcinoma. PMID: 32749562 Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy. PMID: 377161...