目前,PD-1 /PD-L1信号通路的许多环节尚不明确,随着对 PD-1 与肝脏疾病关系的研究逐渐深入,有助于从细胞及分子水平进一步了解肝脏疾病的发生及发展机制,为探索肝脏疾病的免疫治疗提供新的策略。 Ishida Y,Agata Y,Shibahara K,et al.Induced expression of PD-1,a novel member of the immunoglobulin genesuperfa...
参考文献: [1]K. Yoh, Y. Zenke, S. Kitagawa, et al. Genomic screening by multi-gene assay for perioperative targeted therapy in patients with early-stage non-small cell lung cancer: LC-SCRUM-Advantage/MRD. 2023 ESMO abstracts. 12...
4、https://www.gene.com/ 5、http://www.merck.com/index.html
PD-L1PrognosisCancersBioinformatics analysisPD-L1, a target of immune checkpoint blockade, has been proven to take the role of an oncogene in most human tumors. However, the role of PD-L1 in human pan-cancers has not yet been fully investigated. Pan-cancer analysis...
LAG-3(Lymphocyte Activation Gene-3)是另一种在T细胞上表达的免疫检查点,与 CD4 和 CD8 T 细胞的耗竭状态相关。在乳腺癌中,LAG-3 的表达与不良预后因素显著相关,如肿瘤体积大、高分化、HER2-Enrich 和基底样乳腺癌亚型。因此,...
① 表皮生长因子受体(EGFR)突变通过细胞外单调节激酶(ERK)信号转导诱导的PD-L1表达间接促进BCL-2关联的thagenegene-1(BAG-1),EGFR / ERK / PD-L1 / BAG-1反馈环实现ERK信号的重新激活,从而促进Bcl-2相互作用的细胞死亡(BIM)磷酸化介导作用,从而帮助细胞摆脱凋亡。
T. (1999). Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding...
[8]First case report of a dramatic radiographic response to a checkpoint inhibitor in a patient with proficient mismatch repair gene expressing metastatic colorectal cancer. JCO Precis Oncol. 2017;1:1–4 [9]Towards a precision immune checkpoint blockade immunotherapy in patients with colorectal cancer...
[8]First case report of a dramatic radiographic response to a checkpoint inhibitor in a patient with proficient mismatch repair gene expressing metastatic colorectal cancer. JCO Precis Oncol. 2017;1:1–4 [9]Towards a precision immune checkpoint blockade immunotherapy in patients with colorectal cancer...
【Key words 】PD-L1 ;promoter cloning ;dual luciferase reporter gene 程序性细胞死亡蛋白 1 (programmed death-1 , 从而对机体免疫应答过程起负性调节作用[6-7]。 [1] PD-1) PDCD1 , PD-1/PD-L1 为 基因编码的 Ⅰ型跨膜糖蛋白 通路在肿瘤细胞的免疫逃逸中具有重 ...