目前,PD-1 /PD-L1信号通路的许多环节尚不明确,随着对 PD-1 与肝脏疾病关系的研究逐渐深入,有助于从细胞及分子水平进一步了解肝脏疾病的发生及发展机制,为探索肝脏疾病的免疫治疗提供新的策略。 Ishida Y,Agata Y,Shibahara K,et al.Induced expression of PD-1,a novel member of the immunoglobulin genesuperfa...
LAG-3(Lymphocyte Activation Gene-3)抗体 LAG-3(lymphocyte activation gene 3,LAG-3,CD223)和CD4是同源蛋白,但是以更高的亲和力与主要组织相容性复合体Ⅱ类分子(major histocompatibility complex classⅡ,MHCⅡ)结合,主要表达在活化的T淋巴细胞、B淋巴细胞、自然杀伤细胞(natural killer cell, NK)和浆细胞样树突...
8. Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulingene superfamily, upon programmed cell death.The EMBO Journal, Nov 1992, 11 (11): 3887–3895. 9. Agata Y, Kawasaki A, Nishimura H et al. Expression of the PD-1antigen on ...
◆ PD-L1诱导耐药的信号通路和相关因子 ① 表皮生长因子受体(EGFR)突变通过细胞外单调节激酶(ERK)信号转导诱导的PD-L1表达间接促进BCL-2关联的thagenegene-1(BAG-1),EGFR / ERK / PD-L1 / BAG-1反馈环实现ERK信号的重新激活,从而促进Bcl-2相互作用的细胞死亡(BIM)磷酸化介导作用,从而帮助细胞摆脱凋亡。 ②...
[1]BERGER K N,PUJJ.PD⁃1 pathway and its clinical application:A 20 year journey after discovery of the complete human pd⁃1 gene[J]. Gene,2018,638(1):20⁃25. [2]WOO S R,TURNIS M E,GOLDBERG M V,et al. Immune inhi...
Figure 6. Optimization and validation of DDR gene signature scores as predictors of tumor response to anti–PD-L1 therapy 文章小结 这是第一个利用DDR基因家族的差异表达和调控模式来预测治疗反应的文章。研究发现DDR1high表达与非T细胞浸润的免疫“冷”肿瘤相关,而DDR2high表达与T细胞浸润的免疫“热”肿瘤相关...
[19] Ott P.A., Bang Y.-J., Piha-Paul S.A., Razak A.R.A., Bennouna J., Soria J.-C., Rugo H.S., Cohen R.B., O’Neil B.H., Mehnert J.M., et al. T-Cell-Inflamed Gene-Expression Profile, Programmed ...
The polymorphisms of PD-L1 gene and PD-L1 gene copy number could be responsible for PD-L1 mRNA and protein expression.We analyzed PD-L1 protein expression using two IHC assays, mRNA (PD-L1) expression by qRT-PCR, PD-L1 gene promoter region polymorphisms (rs822335 and rs822336) by qPCR...
[8]First case report of a dramatic radiographic response to a checkpoint inhibitor in a patient with proficient mismatch repair gene expressing metastatic colorectal cancer. JCO Precis Oncol. 2017;1:1–4 [9]Towards a precision immune checkpoint blockade immunotherapy in patients with colorectal cancer...
T. (1999). Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 gene encoding...