对实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis,EAU)小鼠模型的研究[29]发现,PD-1在正常和EAU小鼠的视网膜中均表达,而在炎症活动期,PD-L1和PD-L2在眼部浸润的炎症细胞、血管和视网膜中表达明显降低。LEE等[30]发现抑制自身免疫反应可以使EAU炎症好转,PD-1及其配体在眼部的高表达与EAU由活动期向静止期...
[5]. Adeegbe D O, NishikawaH. Natural and induced T regulatory cells in cancer[J]. Frontiers inimmunology, 2013, 4: 190.[6]. Zhang B, ChikumaS, Hori S, Fagarasan S, Honjo T (2016) Nonoverlapping roles of PD-1 and FoxP3in maintaining immune tolerance in a novel autoimmune pancreati...
PD-1缺失的老鼠有很强烈的自身免疫。 [关于EAE模型,全称是experimental autoimmune encephalomyelitis, 是一种免疫实验里常见的模型。主要是把CNS(中枢神经系统)的蛋白,比如myelin相关物质-->PLP, MBP, MOG,和adjuvent混合(常用CFA),皮下打入到老鼠体内进行immunization。老鼠之后会产生抗CNS的免疫细胞,形成自身免疫。]...
[2].杨宝峰. 药理学. 北京: 人民卫生出版社, 2013; 第8版: 7-17. [3].Yu Z, Lennon V A. Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases[J]. The New England Journal of Medicine, 1999, 340(3): 227-228. [4].Brahmer JR, et al. Phase I study...
Since 1992, when PD-1 was isolated, many studies have described the physiological roles of PD-1 signaling, reported relationships between gene polymorphism and autoimmune diseases, and applied PD-1/PD-1 ligand modulation to clinical trials. This review summarizes recent advances and future ...
you have an autoimmune disease (a condition where the body attacks its own cells); you have melanoma of the eye; you were previously given ipilimumab, another medicine for treating melanoma, and experiencedserious side effects because of that medicine; you have been told that ...
Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupuslike autoimmune diseases by disruption of the PD-1 gene encoding anITIM motif-carrying immunoreceptor. Immunity 1999;11:141–51. Freeman GJ, Long AJ, Iwai Y, Bourque ...
该团队此前在Nature Biomedical Engineering上发表的研究已经证明,针对PD-1阳性细胞的特异性蛋白毒素,在动物模型上,成功地逆转了实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis, EAE)的恶化,并且推迟了一型糖尿病(type 1 diabetes, T1D)确立。此次发...
PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease ...
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