对实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis,EAU)小鼠模型的研究[29]发现,PD-1在正常和EAU小鼠的视网膜中均表达,而在炎症活动期,PD-L1和PD-L2在眼部浸润的炎症细胞、血管和视网膜中表达明显降低。LEE等[30]发现抑制自身免疫反应可以使EAU炎症好转,PD-1及其配体在眼部的高表达与EAU由活动期向静止期...
除此之外,PD-1还可以保护我们身体的器官。 PD-1保护器官不受到免疫细胞的攻击 在EAE 模型中,self-react T细胞会表达很高的PD-1,器官会表达很高的PD-L1 PD-1缺失的老鼠有很强烈的自身免疫。 [关于EAE模型,全称是experimental autoimmune encephalomyelitis, 是一种免疫实验里常见的模型。主要是把CNS(中枢神经系统)...
[6]. Zhang B, ChikumaS, Hori S, Fagarasan S, Honjo T (2016) Nonoverlapping roles of PD-1 and FoxP3in maintaining immune tolerance in a novel autoimmune pancreatitis mousemodel. Proc Natl Acad Sci USA 113:8490–8495.[7]. Kumagai S,Togashi Y, Kamada T, et al. The PD-1 expression ...
该研究小组分别以“PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes”和“Newly Generated CD4 T Cells Maintain Dangerous Autoimmune Potential: Fas- and Perforin-Independent Autoimmunity Controlled by Programmed Death-1”...
为了模拟PD-L1-PD-1的自然结合,Immunocore设计了双特异性PD-1激动剂(*ImmTAAI®分子),特异性地结合靶细胞,并同时激活自身反应性T细胞上的PD-1。 *ImmTAAI® (Immune Modulating Monoclonal TCRs Against Autoimmune Disease)将重组PD-L1或抗PD-1激动剂抗...
[3].Yu Z, Lennon V A. Mechanism of Intravenous Immune Globulin Therapy in Antibody-Mediated Autoimmune Diseases[J]. The New England Journal of Medicine, 1999, 340(3): 227-228. [4].Brahmer JR, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory ...
you have an autoimmune disease (a condition where the body attacks its own cells); you have melanoma of the eye; you were previously given ipilimumab, another medicine for treating melanoma, and experiencedserious side effects because of that medicine; you have been told that ...
今天为大家介绍一篇2023年发表在Nature Communication的文章,题目为“An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases”。本文中,作者开发了一种两步双锚定策略,利用点击化学和物理插膜技术增强PD-L1 在细胞上的固定,并将其应用于缓解自身免疫病如I型糖尿病和...
Autoimmune diseases therapeutic agent consisting of pd-1 agonistProvided is a prophylactic, symptom progress-suppressive, and/or therapeutic agent for an autoimmune disease. The agent lowers the risk of infections and reduces the burden of administration to patients. The prophylactic, symptom progress-...
both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 ...