第一篇论文题为:LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity(LAG-3和PD-1协同作用于CD8+T细胞,驱动T细胞耗竭,阻碍自分泌IFN-γ依赖性抗...
耗竭中期 (T cellExhaustionintermediate,TexInt):TexProg2逐渐失去TCF1,分裂并转换为第三个阶段--中期Tex亚群,此时耗竭T重新获得一些细胞毒性效应功能,尤其在PD-L1阻断后增加。 耗竭末期(T cellExhaustionterminally, Tex Term):高表达PD-1的耗竭...
第一篇论文题为:LAG-3 and PD-1 synergize on CD8+T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity(LAG-3和PD-1协同作用于CD8+T细胞,驱动T细胞耗竭,阻碍自分泌IFN-γ依赖性抗肿瘤免疫)。 克服免疫介导的PD-1阻断剂的耐药仍然是一个重大临床挑战。在黑色素瘤...
PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection [J]. Journal of viral hepatitis, 2010, 17(7): 453-458.[13] Suarez-Gestal M, Ferreiros-Vidal I, Ortiz J A, et al. Analysis of the functional relevance of a putative regulatory SNP of PDCD1, PD1.3, ...
【编者按】所谓T细胞耗竭(TCellExhaustion)是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原和炎症,精疲力竭的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,这主要通过阻断PD-1/PD-L1等免疫抑制性信号通路,逆转肿瘤免疫微环境,恢复T细胞的抗肿瘤活性;另...
5. Jiang, Y., Li, Y. & Zhu, B. T-cell exhaustion in the tumor microenvironment. Cell Death Dis 6, e1792 (2015).6. Gato-Canas, M. et al. PDL1 Signals through Conserved Sequence Motifs to Overcome Interferon-Mediated Cytotoxicity. Cell Rep 20, 1818-1829 (2017).7. Tu, X. et al...
PD-1全称为Cell Death protein，扮演着在抑制免疫反应和促进自我耐受方面的关键角色。PD-1通过调节T细胞活性、激活抗原特异性T细胞凋亡及抑制调节性T细胞的凋亡等途径发挥作用。PD-L1是一种参与免疫应答共同抑制因子的跨膜蛋白，能与PD-1结合以减少PD-1阳性细胞的增殖，抑制细胞因子分泌并诱导细胞凋亡。PD-...
Blockade of this pathway using antibodies against the PD ligand 1 (PD-L1) restores CD8+ T-cell function and reduces viral load. However, the mechanisms that underlie the induction of exhaustion are not completely understood. To investigate the role of PD-1 signaling in chronic viral infections,...
PD-1全名为 Cell Death protein,即细胞死亡蛋白1。PD-1通过以下途径在抑制免疫反应和促进自我耐受方面发挥着重要作用:①调节T细胞活性、②激活抗原特异性T细胞凋亡、③抑制调节性T细胞的凋亡。程序性细胞死亡配体1(PD-L1)是一种跨膜蛋白,被认为是免疫应答的共同抑制因子,它可以与PD-1结合以减少PD-1阳性细胞的增殖...
12. Dammeijer, F., et al., The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes. Cancer Cell, 2020. 38(5): p. 685-700 e8.13. Yates, K.B., et al., Epigenetic scars of CD8(+) T cell exhaustion persist after cure of chronic infection in humans. ...